Detailed information of TA system TA033993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4464838..4465365
• Replicon: chromosome
• Accession: NZ_AP021972
• Organism: Klebsiella sp. WP3-W18-ESBL-02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H7R56_RS21510
• Protein ID: WP_094760972.1
• Coordinates: 4464838..4465113 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H7R56_RS21515
• Protein ID: WP_094760973.1
• Coordinates: 4465117..4465365 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R56_RS21500	4462338..4463725	-	1388	Protein_4210	type VI secretion system tip protein VgrG	-
H7R56_RS21505	4463928..4464722	-	795	WP_094760971.1	helix-turn-helix transcriptional regulator	-
H7R56_RS21510	4464838..4465113	-	276	WP_094760972.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7R56_RS21515	4465117..4465365	-	249	WP_094760973.1	ribbon-helix-helix domain-containing protein	Antitoxin
H7R56_RS21520	4465442..4466275	-	834	WP_094760974.1	DUF4942 domain-containing protein	-
H7R56_RS21525	4466391..4466732	-	342	WP_094760975.1	TA system toxin CbtA family protein	-
H7R56_RS21530	4466776..4467117	-	342	WP_094760976.1	type IV toxin-antitoxin system YeeU family antitoxin	-
H7R56_RS21535	4467140..4467361	-	222	WP_094760977.1	DUF987 family protein	-
H7R56_RS21540	4467358..4467867	-	510	WP_171862414.1	DNA repair protein RadC	-
H7R56_RS21545	4467879..4468298	-	420	WP_094760978.1	antirestriction protein	-
H7R56_RS21550	4468412..4469230	-	819	WP_094760979.1	DUF945 domain-containing protein	-
H7R56_RS21555	4469347..4469577	-	231	WP_094760980.1	hypothetical protein	-
H7R56_RS21560	4469574..4469807	-	234	WP_094760981.1	DUF905 domain-containing protein	-
H7R56_RS21565	4469913..4470188	-	276	WP_182928402.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-42)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10981.34 Da
• Isoelectric Point: 4.8888

>T33993 WP_094760972.1 NZ_AP021972:c4465113-4464838 [Klebsiella sp. WP3-W18-ESBL-02]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCAGLAAHPAIGVQQPRYEPREVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Nucleotide

• Length: 276 bp

>T33993 NZ_AP021972:c4465113-4464838 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGACTTGGAGCGTATCTACCGTTTTGCCCTTCAGTATAGCCGCCAGCA
CGCCGATGACGTTTTGGATCGCCTGATTACTGGATGCGCTGGCCTTGCAGCGCATCCGGCAATTGGCGTACAGCAGCCTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTTGATGATTACGAGGTTCACTACGAACTTCGTGACAATGATATCTAT
ATCGTGGATCTCTGGCATACAAAAGAAGAACGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8987.33 Da
• Isoelectric Point: 8.8294

>AT33993 WP_094760973.1 NZ_AP021972:c4465365-4465117 [Klebsiella sp. WP3-W18-ESBL-02]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSNMVDFANRLK
KA

Nucleotide

• Length: 249 bp

>AT33993 NZ_AP021972:c4465365-4465117 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGGTTCGCTTACTAAACAAACCATCAGCGCACAGATACCAGTGGAGTTGGCTGCTGCTGTTGAAAATCTGGCAATTGA
GTTAGATCGTTCTAAGAGCTGGATTATTAAGGAAGCGTTGACCAGTATGCTGGCCGAAAGAGAACGGCGTCATCAGAGTA
TCCAGGCCGGTCTTGCCGATGTGGATGCTGGTCGTGTGGTGAGTCATTCGAACATGGTGGATTTCGCTAACCGTTTAAAG
AAAGCTTGA