33991

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 4020587..4021266 Replicon chromosome
Accession NZ_AP021972
Organism Klebsiella sp. WP3-W18-ESBL-02

Toxin (Protein)


Gene name ykfI Uniprot ID A0A1B7JLK7
Locus tag H7R56_RS19335 Protein ID WP_003031349.1
Coordinates 4020925..4021266 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID A0A1B7JLJ2
Locus tag H7R56_RS19330 Protein ID WP_003031347.1
Coordinates 4020587..4020904 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R56_RS19305 4016680..4018677 - 1998 WP_032939120.1 choline BCCT transporter BetT -
H7R56_RS19310 4019181..4019372 + 192 Protein_3788 DUF905 family protein -
H7R56_RS19315 4019386..4019847 + 462 WP_003031344.1 antirestriction protein -
H7R56_RS19320 4019863..4020339 + 477 WP_003031345.1 RadC family protein -
H7R56_RS19325 4020348..4020569 + 222 WP_003031346.1 DUF987 domain-containing protein -
H7R56_RS19330 4020587..4020904 + 318 WP_003031347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H7R56_RS19335 4020925..4021266 + 342 WP_003031349.1 type IV toxin-antitoxin system toxin YkfI Toxin
H7R56_RS19340 4021882..4022433 - 552 WP_128350872.1 recombinase family protein -
H7R56_RS19345 4022655..4023056 - 402 WP_182928266.1 tail fiber assembly protein -
H7R56_RS19350 4023715..4024152 - 438 Protein_3796 phage tail protein -
H7R56_RS19355 4024152..4024832 - 681 WP_182928340.1 DUF2612 domain-containing protein -
H7R56_RS19360 4024829..4026028 - 1200 WP_153983799.1 baseplate J/gp47 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4019386..4075767 56381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12921.01 Da        Isoelectric Point: 9.6543

>T33991 WP_003031349.1 NZ_AP021972:4020925-4021266 [Klebsiella sp. WP3-W18-ESBL-02]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

>T33991 NZ_AP021972:4020925-4021266 [Klebsiella sp. WP3-W18-ESBL-02]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12094.74 Da        Isoelectric Point: 7.0370

>AT33991 WP_003031347.1 NZ_AP021972:4020587-4020904 [Klebsiella sp. WP3-W18-ESBL-02]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIEYRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT33991 NZ_AP021972:4020587-4020904 [Klebsiella sp. WP3-W18-ESBL-02]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JLK7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JLJ2

References