33978

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1109511..1110037 Replicon chromosome
Accession NZ_AP021972
Organism Klebsiella sp. WP3-W18-ESBL-02

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag H7R56_RS05365 Protein ID WP_000323025.1
Coordinates 1109511..1109798 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag H7R56_RS05370 Protein ID WP_000534858.1
Coordinates 1109798..1110037 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R56_RS05340 1105265..1106257 + 993 WP_106926080.1 RNA polymerase sigma factor RpoS -
H7R56_RS05345 1106319..1106723 - 405 WP_106926082.1 MarR family transcriptional regulator -
H7R56_RS05350 1106865..1107458 + 594 WP_106926084.1 UbiX family flavin prenyltransferase -
H7R56_RS05355 1107458..1108885 + 1428 WP_106926086.1 UbiD family decarboxylase -
H7R56_RS05360 1108896..1109132 + 237 WP_106926088.1 hypothetical protein -
H7R56_RS05365 1109511..1109798 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
H7R56_RS05370 1109798..1110037 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
H7R56_RS05375 1110300..1111223 - 924 Protein_1055 cation transporter -
H7R56_RS05380 1111423..1111995 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
H7R56_RS05385 1112638..1113978 - 1341 WP_000589001.1 ISNCY family transposase -
H7R56_RS05390 1114056..1114208 + 153 WP_106926090.1 type I toxin-antitoxin system Hok family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T33978 WP_000323025.1 NZ_AP021972:c1109798-1109511 [Klebsiella sp. WP3-W18-ESBL-02]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T33978 NZ_AP021972:c1109798-1109511 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT33978 WP_000534858.1 NZ_AP021972:c1110037-1109798 [Klebsiella sp. WP3-W18-ESBL-02]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT33978 NZ_AP021972:c1110037-1109798 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References