Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 889956..890616 Replicon chromosome
Accession NZ_AP021972
Organism Klebsiella sp. WP3-W18-ESBL-02

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag H7R56_RS04320 Protein ID WP_106925783.1
Coordinates 890203..890616 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag H7R56_RS04315 Protein ID WP_106925781.1
Coordinates 889956..890222 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R56_RS04290 885097..886530 - 1434 WP_106925771.1 6-phospho-beta-glucosidase BglA -
H7R56_RS04295 886651..887379 - 729 WP_106925773.1 MurR/RpiR family transcriptional regulator -
H7R56_RS04300 887431..887745 + 315 WP_106925775.1 N(4)-acetylcytidine aminohydrolase -
H7R56_RS04305 887904..888566 + 663 WP_106925777.1 hemolysin III family protein -
H7R56_RS04310 888729..889712 - 984 WP_106925779.1 tRNA-modifying protein YgfZ -
H7R56_RS04315 889956..890222 + 267 WP_106925781.1 FAD assembly factor SdhE Antitoxin
H7R56_RS04320 890203..890616 + 414 WP_106925783.1 protein YgfX Toxin
H7R56_RS04325 890619..891140 - 522 WP_106925785.1 flavodoxin FldB -
H7R56_RS04330 891243..892139 + 897 WP_106925787.1 site-specific tyrosine recombinase XerD -
H7R56_RS04335 892162..892875 + 714 WP_106925789.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H7R56_RS04340 892881..894614 + 1734 WP_182928523.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16348.24 Da        Isoelectric Point: 11.7122

>T33976 WP_106925783.1 NZ_AP021972:890203-890616 [Klebsiella sp. WP3-W18-ESBL-02]
VVLWQSDLRVSWRSQWLSLLLHGLVAAFVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHSHQGEIKLLMDSRLRWRNQ
EWDIQGAPWMLNSGMMLRIRRPGGRRQHLWLAADSMNPEEWRDLRRILMQQPAATKD

Download         Length: 414 bp

>T33976 NZ_AP021972:890203-890616 [Klebsiella sp. WP3-W18-ESBL-02]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCTCACAGTGGCTCTCTTTATTGCTCCACGGCCTGGTGGCGGC
TTTTGTGCTGCTGATGCCCTGGCCGTTGAGCTATACCCCTCTGTGGCTTATTTTGCTGTCGCTGGTGGTGTTTGACTGCG
TTCGCAGCCAGCGGCGCATTCATTCCCACCAGGGGGAAATTAAGCTACTGATGGATTCCCGGCTGCGCTGGCGTAATCAG
GAGTGGGATATTCAGGGGGCTCCGTGGATGCTGAATTCCGGCATGATGTTGCGGATTCGCCGTCCTGGCGGGCGGCGTCA
GCATTTATGGCTCGCGGCGGACAGCATGAATCCGGAAGAGTGGCGCGACCTGCGGCGGATACTTATGCAGCAGCCCGCGG
CCACCAAAGACTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10456.98 Da        Isoelectric Point: 5.6125

>AT33976 WP_106925781.1 NZ_AP021972:889956-890222 [Klebsiella sp. WP3-W18-ESBL-02]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDEDKALFIRLLECDDPDLFNWLMNHGKPADANLQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT33976 NZ_AP021972:889956-890222 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGACATCAATAATAAAGCCCGTATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
CTTTGAGCACGAGTACGACACGCTGAGCGACGAAGATAAAGCACTCTTTATTCGTCTGCTGGAATGCGACGATCCTGACC
TCTTCAACTGGCTGATGAATCACGGCAAACCGGCTGACGCTAACCTCCAGCGCATGGTGCAACTTATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References