Detailed information of TA system TA033935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4819697..4820210
• Replicon: chromosome
• Accession: NZ_AP021950
• Organism: Klebsiella quasipneumoniae strain WP3-W18-CRE-02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A663BE04
• Locus tag: H7R86_RS23755
• Protein ID: WP_017900571.1
• Coordinates: 4819697..4819978 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H7R86_RS23760
• Protein ID: WP_064162488.1
• Coordinates: 4819968..4820210 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R86_RS23740	4814739..4816394	+	1656	WP_080936223.1	alpha,alpha-phosphotrehalase	-
H7R86_RS23745	4816780..4818918	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
H7R86_RS23750	4819229..4819693	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
H7R86_RS23755	4819697..4819978	-	282	WP_017900571.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7R86_RS23760	4819968..4820210	-	243	WP_064162488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H7R86_RS23765	4820288..4822198	-	1911	WP_004206509.1	BglG family transcription antiterminator	-
H7R86_RS23770	4822221..4823372	-	1152	WP_080936226.1	lactonase family protein	-
H7R86_RS23775	4823440..4824180	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11082.93 Da
• Isoelectric Point: 10.4123

>T33935 WP_017900571.1 NZ_AP021950:c4819978-4819697 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T33935 NZ_AP021950:c4819978-4819697 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT33935 WP_064162488.1 NZ_AP021950:c4820210-4819968 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT33935 NZ_AP021950:c4820210-4819968 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGCTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A663BE04