Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1668163..1669955 Replicon chromosome
Accession NZ_AP021950
Organism Klebsiella quasipneumoniae strain WP3-W18-CRE-02

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag H7R86_RS08285 Protein ID WP_064178420.1
Coordinates 1668606..1669955 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H7R86_RS08280 Protein ID WP_064178387.1
Coordinates 1668163..1668609 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R86_RS08265 1664458..1665456 + 999 WP_004201626.1 galactose/glucose ABC transporter substrate-binding protein MglB -
H7R86_RS08270 1665575..1667095 + 1521 WP_004201625.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
H7R86_RS08275 1667111..1668121 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
H7R86_RS08280 1668163..1668609 - 447 WP_064178387.1 helix-turn-helix domain-containing protein Antitoxin
H7R86_RS08285 1668606..1669955 - 1350 WP_064178420.1 type II toxin-antitoxin system HipA family toxin Toxin
H7R86_RS08290 1670070..1670801 - 732 WP_008804033.1 outer membrane permeability protein SanA -
H7R86_RS08295 1671077..1671961 - 885 WP_017899328.1 cytidine deaminase -
H7R86_RS08300 1672090..1672785 - 696 WP_004201621.1 CidB/LrgB family autolysis modulator -
H7R86_RS08305 1672775..1673179 - 405 WP_004201620.1 CidA/LrgA family protein -
H7R86_RS08310 1673537..1674469 + 933 WP_004201619.1 tRNA dihydrouridine(16) synthase DusC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galF / cpsACP / wzi / wza / wcaJ / gnd / manC / manB / wbtL / ugd / wbtL 1625095..1882577 257482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-410)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51050.94 Da        Isoelectric Point: 4.8038

>T33924 WP_064178420.1 NZ_AP021950:c1669955-1668606 [Klebsiella quasipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTAMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL

Download         Length: 1350 bp

>T33924 NZ_AP021950:c1669955-1668606 [Klebsiella quasipneumoniae]
ATGGAAACATTAACGGTACAAGCCTTTCTCAATGCGGAGTGGCAAGACATTGCGTTGATAAAATTCCCCGGTAGTGAGCA
AGGGGACTGGTTTACAACACAAATCGACTATCTTACCGATTACGCCATCGACTTTCTGGAACGCGATGACTATCACGCCG
TGTCGCTCAACCACCCCGTTTCGCTTTATTTTGAGGATCACGGAAATCCTGGATGGTTAAGATTTATAGACGATATCATT
CCAAGCGGCGCCAGCCGACGTTACTGGGTTAACTTTTTAGATATCAGTGAACTTCCTCAGGGCCAACAGAATTTCATCTT
GCTCAAATTCGGCACGATGTCGCCAGTGGGAAATTTACGCATTAAAGACTCGGTGCCGGACTGGGATAGTCTGGCAAGCA
GTAAAACGTTCTCTGTCACTGATGTCATGAATCGTGCCAGTGATTTTCTCGACTATGCCCAGGAACGAGGAGCCGCAGCA
GGAGGGGCTACAGGTGCTGGCGGCGAAGCGCCGAAACTGCTGCTGCGCTGTAGTAAGAGGCAAGAAATCTGGATCGATAC
CTGGCAAAACGAACCAGGCTCTGACGATCTTTATTACCTGGTGAAGTATCCGCGAGGCAGCAGAAGCGAAGTGGACTGTA
ATATTTTACGCGCCGAATTTCATTACTACCATGAACTCACCGCCATGGGCTTTTCGACTATTCCTGTCGATAATATGCGT
CTTGAGGAGGGGCTACATTATCCCTCTCTCTGGTTGCCGCGATTTGATATCAGAAGAGACGGTGATGGCCGGATAATGAG
ATTGGGAATGGAGTCAGTCTATTCTCTGTTACAAAAAGCGCCAGCGACGATACTCGATCATGAAACCACGCTGCGGATCC
TGATCGAAAAGATCACATCCAGTCATATGGTAAGAGTACAGAATTATCGCTTTGATGTTCAAGGATTTATCATAGATTGG
GTACGTCGAGACTTATTAAACATTATTTTTGGCAATAGTGATAACCATGGACGTAATACTGCATTTATGAAAGCAGATAA
TGAAATTACCCTTGCGCCAATCTACGATTTTGCACCAATGAAAGCCGACCCGGAAGGTATACCGCGCACGATGAAGTGGT
CATTAGCCTGCGAATCAGGAGGCGAATACAACTTTGGCGCCATCGCACAAGCTTTGGCTGAATGGATCGCCCCTGACACA
TTGCTTAATGCTTTAAGAGAAACCGCATCTCAACTCATTGATTTACCATCCCGTCTTAAAGCACGCGGCGTTCCTGTTCA
GATTCTGGAAATGCCATCAATTGGTTTTAAATTTATACCTGACAAACTCGCTCGCTGGGGGCTGTTATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16510.20 Da        Isoelectric Point: 10.5137

>AT33924 WP_064178387.1 NZ_AP021950:c1668609-1668163 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT33924 NZ_AP021950:c1668609-1668163 [Klebsiella quasipneumoniae]
ATGAAGACCCTGAATAAAAAAGAAACAGAAATCCAAAATACCTTAGCCAGGCTGCGGGCGGAGAACCCACCATCCCTACC
CGCCACCGAGGTAACGGCTACGGAAAAAAAAGCTCGTTCAGAGATAAGCAGACAACGCGTCTCGACTGGTTTAAAAAAAG
TCAAAACGATCGATCGTCAGGCGGTCATTCACGCCATTATCCATGACATCATGCTAGGTGCCATCAGCCAGGGAGAGGCC
CTGAAAAAACTGAGAGTAGAAGTTCTGGGTTTACGCCAGGATGAATATGCCCGGCTAGTGGATGTCTCTCGTAAGACCTT
ATCTGATGTGGAAAATGATAAAGGCAATTATTCTGCTGAGATCATTAATAAAATCTTTAAGCCGTTTGGCCTTGAAACAG
GACTCGTCCCTATTTCTAAAACACTCATTTCTTCTCTATTTAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References