Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 92591..93126 | Replicon | plasmid pWP2-S18-ESBL-08_1 |
| Accession | NZ_AP021947 | ||
| Organism | Escherichia coli strain WP2-S18-ESBL-08 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0VJJ7 |
| Locus tag | H7R07_RS25410 | Protein ID | WP_000222760.1 |
| Coordinates | 92591..92878 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | H7R07_RS25415 | Protein ID | WP_001132900.1 |
| Coordinates | 92875..93126 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R07_RS25385 | 88174..89395 | - | 1222 | Protein_86 | ISL3 family transposase | - |
| H7R07_RS25390 | 89495..89859 | + | 365 | Protein_87 | IS1 family transposase | - |
| H7R07_RS25395 | 89914..90693 | - | 780 | WP_001513481.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| H7R07_RS25400 | 90693..91715 | - | 1023 | WP_000255956.1 | IS21-like element IS100 family transposase | - |
| H7R07_RS25405 | 91804..92151 | + | 348 | Protein_90 | IS1-like element IS1A family transposase | - |
| H7R07_RS25410 | 92591..92878 | - | 288 | WP_000222760.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H7R07_RS25415 | 92875..93126 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H7R07_RS25420 | 93199..93390 | - | 192 | WP_053270994.1 | hypothetical protein | - |
| H7R07_RS25425 | 94093..94950 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| H7R07_RS25430 | 94943..95425 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| H7R07_RS25435 | 95418..95492 | - | 75 | WP_001442103.1 | RepA leader peptide Tap | - |
| H7R07_RS25440 | 95724..95981 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| H7R07_RS25445 | 96265..96471 | - | 207 | WP_001351576.1 | type I toxin-antitoxin system Hok family toxin | - |
| - | 96458..96519 | + | 62 | NuclAT_1 | - | - |
| - | 96458..96519 | + | 62 | NuclAT_1 | - | - |
| - | 96458..96519 | + | 62 | NuclAT_1 | - | - |
| - | 96458..96519 | + | 62 | NuclAT_1 | - | - |
| H7R07_RS25450 | 96775..96849 | - | 75 | Protein_99 | endonuclease | - |
| H7R07_RS25455 | 97095..97307 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| H7R07_RS25460 | 97443..98003 | - | 561 | WP_032072881.1 | fertility inhibition protein FinO | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | iucA / iucB / iucC / iucD / iutA / vat / iroN / iroE / iroD / iroC / iroB | 1..210712 | 210712 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11105.15 Da Isoelectric Point: 10.5832
>T33907 WP_000222760.1 NZ_AP021947:c92878-92591 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T33907 NZ_AP021947:c92878-92591 [Escherichia coli]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT33907 WP_001132900.1 NZ_AP021947:c93126-92875 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT33907 NZ_AP021947:c93126-92875 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|