33869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4170872..4171467 Replicon chromosome
Accession NZ_AP021944
Organism Escherichia coli strain WP2-S18-ESBL-07

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag H7R05_RS19935 Protein ID WP_000239579.1
Coordinates 4170872..4171222 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2J1DIF8
Locus tag H7R05_RS19940 Protein ID WP_001223209.1
Coordinates 4171216..4171467 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R05_RS19915 4166318..4167340 - 1023 WP_024251350.1 ABC transporter permease -
H7R05_RS19920 4167354..4168856 - 1503 WP_000205810.1 sugar ABC transporter ATP-binding protein -
H7R05_RS19925 4168996..4169952 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H7R05_RS19930 4170262..4170792 + 531 WP_000055075.1 inorganic diphosphatase -
H7R05_RS19935 4170872..4171222 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
H7R05_RS19940 4171216..4171467 - 252 WP_001223209.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H7R05_RS19945 4171679..4172020 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
H7R05_RS19950 4172023..4175802 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T33869 WP_000239579.1 NZ_AP021944:c4171222-4170872 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T33869 NZ_AP021944:c4171222-4170872 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.4201

>AT33869 WP_001223209.1 NZ_AP021944:c4171467-4171216 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWSKSTPAGD
EIW

Download         Length: 252 bp

>AT33869 NZ_AP021944:c4171467-4171216 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGAGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2J1DIF8

References