33853

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1398758..1399383 Replicon chromosome
Accession NZ_AP021944
Organism Escherichia coli strain WP2-S18-ESBL-07

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag H7R05_RS06830 Protein ID WP_000911331.1
Coordinates 1398985..1399383 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag H7R05_RS06825 Protein ID WP_000450524.1
Coordinates 1398758..1398985 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R05_RS06800 1394561..1395031 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
H7R05_RS06805 1395031..1395603 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
H7R05_RS06810 1395749..1396627 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
H7R05_RS06815 1396644..1397678 + 1035 WP_061354635.1 outer membrane protein assembly factor BamC -
H7R05_RS06820 1397891..1398604 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
H7R05_RS06825 1398758..1398985 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
H7R05_RS06830 1398985..1399383 + 399 WP_000911331.1 tRNA(fMet)-specific endonuclease VapC Toxin
H7R05_RS06835 1399530..1400393 + 864 WP_001267507.1 neutral zinc metallopeptidase -
H7R05_RS06840 1400408..1402423 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
H7R05_RS06845 1402497..1403195 + 699 WP_000679812.1 esterase -
H7R05_RS06850 1403305..1403505 - 201 WP_089631931.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T33853 WP_000911331.1 NZ_AP021944:1398985-1399383 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T33853 NZ_AP021944:1398985-1399383 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGGTGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT33853 WP_000450524.1 NZ_AP021944:1398758-1398985 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT33853 NZ_AP021944:1398758-1398985 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References