Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 15673..16241 Replicon plasmid pWP2-S18-CRE-03_2
Accession NZ_AP021942
Organism Aeromonas veronii strain WP2-S18-CRE-03

Toxin (Protein)


Gene name parE Uniprot ID A0A0D0R3P1
Locus tag H7R57_RS23365 Protein ID WP_011222050.1
Coordinates 15948..16241 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3S7DUI6
Locus tag H7R57_RS23360 Protein ID WP_043849769.1
Coordinates 15673..15960 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R57_RS23330 10881..11645 + 765 WP_001389365.1 IS6-like element IS6100 family transposase -
H7R57_RS23335 11895..12533 + 639 WP_008166580.1 AAA family ATPase -
H7R57_RS23340 12555..12776 + 222 WP_011178357.1 chromosome partitioning protein ParB -
H7R57_RS23345 12885..13196 + 312 WP_077268002.1 hypothetical protein -
H7R57_RS23350 13353..14702 + 1350 WP_128297848.1 replication protein -
H7R57_RS23355 14783..15028 + 246 WP_128297849.1 hypothetical protein -
H7R57_RS23360 15673..15960 + 288 WP_043849769.1 CopG family ribbon-helix-helix protein Antitoxin
H7R57_RS23365 15948..16241 + 294 WP_011222050.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R57_RS23370 16256..16786 + 531 WP_043849768.1 hypothetical protein -
H7R57_RS23375 16897..17133 + 237 WP_156152877.1 type II toxin-antitoxin system CcdA family antitoxin -
H7R57_RS23380 17137..17424 + 288 WP_043849767.1 hypothetical protein -
H7R57_RS23385 17711..18586 + 876 WP_128345676.1 replication initiation protein -
H7R57_RS23390 18763..19053 - 291 WP_182928088.1 hypothetical protein -
H7R57_RS23395 19262..19675 + 414 WP_043849774.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrVC4 / blaVEB-1 / ant(2'')-Ia / dfrA14 - 1..22511 22511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10890.71 Da        Isoelectric Point: 10.8518

>T33847 WP_011222050.1 NZ_AP021942:15948-16241 [Aeromonas veronii]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Download         Length: 294 bp

>T33847 NZ_AP021942:15948-16241 [Aeromonas veronii]
ATGCCACAAGTGATCCTCTCTCCGGCTGCTCTGCGTGACCTTAAACGGCTGCGCGAGTTCTTGCACAGTAAGAGCCCGGT
TGTTGCACAGCGAGCAGCCCAAACCATCCGTTCGGCGCTGGCCCAGCTCGGGCAACAACCCGCGATGGGGCGTCCTATTG
AAGGGCTCCCGGAGGTGTTCCGCGAGTGGGTTATCCCCTTTGGGGACAGTGGTTATCTGGCGCGTTACCGCCTAGAGGGC
GAAACCGTAGTGATCTTGGCTCTGCGTCACCAGCGCGAAGCCGGGTTTATTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10892.16 Da        Isoelectric Point: 5.1897

>AT33847 WP_043849769.1 NZ_AP021942:15673-15960 [Aeromonas veronii]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEEADQWLA
GWGTEIEGGAPACHK

Download         Length: 288 bp

>AT33847 NZ_AP021942:15673-15960 [Aeromonas veronii]
ATGTCCGCAGCTACCAAACCCATGTCTATCAAACTTGATAGCGATACCCAAAGCCGGATCAAGCAGCTAGCTGCTGCCCG
CGACCGTTCAGCGCACTGGATGATGCGCGAAGCTATCACCCAGTATGTTGAGCGCGAAGAGCGCAAGGAGGCGTTCCGCC
GCGATACCCTCGATGCTTGGCAGGAGTTTCAGGAGACTGGTTTGCATGTCTCTCTTGAGGAGGCCGATCAGTGGTTGGCT
GGTTGGGGCACCGAGATTGAAGGTGGTGCACCTGCATGCCACAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D0R3P1

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DUI6

References