Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4325304..4325899 Replicon chromosome
Accession NZ_AP021935
Organism Escherichia coli strain WP2-W18-ESBL-10

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag H7X62_RS20410 Protein ID WP_019842229.1
Coordinates 4325549..4325899 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag H7X62_RS20405 Protein ID WP_001223213.1
Coordinates 4325304..4325555 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7X62_RS20395 4320969..4324748 + 3780 WP_001550503.1 autotransporter assembly complex protein TamB -
H7X62_RS20400 4324751..4325092 + 342 WP_001550504.1 gamma-glutamylcyclotransferase -
H7X62_RS20405 4325304..4325555 + 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
H7X62_RS20410 4325549..4325899 + 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
H7X62_RS20415 4326103..4326633 - 531 WP_000055075.1 inorganic diphosphatase -
H7X62_RS20420 4326943..4327899 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
H7X62_RS20425 4328031..4329533 + 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
H7X62_RS20430 4329547..4330569 + 1023 WP_001550507.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T33838 WP_019842229.1 NZ_AP021935:4325549-4325899 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T33838 NZ_AP021935:4325549-4325899 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT33838 WP_001223213.1 NZ_AP021935:4325304-4325555 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT33838 NZ_AP021935:4325304-4325555 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References