Detailed information of TA system TA033752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1020316..1020884
• Replicon: chromosome
• Accession: NZ_AP021927
• Organism: Aeromonas caviae strain WP2-W18-ESBL-01

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: H7R60_RS04980
• Protein ID: WP_101617266.1
• Coordinates: 1020316..1020609 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H7R60_RS04985
• Protein ID: WP_101617265.1
• Coordinates: 1020597..1020884 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R60_RS04960	1016313..1017581	+	1269	WP_011191342.1	IS4-like element ISApu1 family transposase	-
H7R60_RS04965	1017612..1018994	+	1383	WP_182935891.1	SEL1-like repeat protein	-
H7R60_RS04970	1019432..1019704	-	273	WP_139743096.1	hypothetical protein	-
H7R60_RS04975	1019725..1020108	-	384	WP_139743097.1	hypothetical protein	-
H7R60_RS04980	1020316..1020609	-	294	WP_101617266.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7R60_RS04985	1020597..1020884	-	288	WP_101617265.1	CopG family ribbon-helix-helix protein	Antitoxin
H7R60_RS04990	1021089..1021718	+	630	WP_182935892.1	AAA family ATPase	-
H7R60_RS04995	1021739..1021936	+	198	WP_161508007.1	chromosome partitioning protein ParB	-
H7R60_RS05000	1022029..1022346	+	318	Protein_937	conjugal transfer protein TrbF	-
H7R60_RS05005	1022343..1023392	+	1050	WP_011191356.1	P-type conjugative transfer protein TrbG	-
H7R60_RS05010	1023389..1024609	+	1221	WP_011191355.1	TrbI/VirB10 family protein	-
H7R60_RS05015	1024609..1024848	+	240	WP_018429611.1	DUF2274 domain-containing protein	-
H7R60_RS05020	1024845..1025741	-	897	WP_011191354.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1009995..1069741	59746

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10980.79 Da
• Isoelectric Point: 10.6871

>T33752 WP_101617266.1 NZ_AP021927:c1020609-1020316 [Aeromonas caviae]
MPPVIFAPAALRDLQRLREFLRPKSPQVAQRAATTIQLSLRQLAAQPSMGRPIEGLPEAFREWVIPFGDSGYLARYRIEP
DVIVVLAVRHQREVGYS

Nucleotide

• Length: 294 bp

>T33752 NZ_AP021927:c1020609-1020316 [Aeromonas caviae]
ATGCCACCAGTGATCTTTGCCCCTGCCGCCCTGCGAGACCTGCAACGCCTACGTGAATTCCTGCGCCCTAAAAGCCCGCA
GGTCGCACAGCGGGCCGCAACAACAATCCAGCTGTCCCTACGCCAGCTCGCAGCCCAACCCTCAATGGGCCGCCCCATAG
AAGGACTGCCAGAGGCGTTTCGTGAGTGGGTGATCCCCTTTGGTGACAGCGGCTATTTAGCCCGCTATCGCATTGAACCG
GATGTCATCGTGGTGCTCGCTGTCCGCCATCAACGCGAAGTTGGCTACTCATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11047.15 Da
• Isoelectric Point: 4.7091

>AT33752 WP_101617265.1 NZ_AP021927:c1020884-1020597 [Aeromonas caviae]
MPTQSKPVSIKLDADTQERIKRLATSRERSAHWLMREAISQYVEREELRETFHRDTLEAWQEFQETGQYATAQDVDQWLA
SWGTDAEGAPPACHQ

Nucleotide

• Length: 288 bp

>AT33752 NZ_AP021927:c1020884-1020597 [Aeromonas caviae]
ATGCCCACACAATCCAAACCGGTCTCGATCAAACTCGACGCCGATACCCAGGAACGCATCAAACGCCTGGCAACCTCCCG
CGAACGCTCAGCCCATTGGCTCATGCGCGAAGCCATCAGCCAGTATGTCGAGCGCGAAGAACTGCGCGAGACCTTCCACC
GCGACACTCTGGAGGCCTGGCAGGAGTTCCAGGAGACCGGCCAGTATGCCACCGCTCAAGATGTGGATCAGTGGCTAGCC
TCTTGGGGCACTGATGCCGAAGGAGCGCCTCCTGCATGCCACCAGTGA