Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4005911..4006530 Replicon chromosome
Accession NZ_AP021909
Organism Klebsiella pneumoniae strain WP2-S17-ESBL-02

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H7R06_RS19340 Protein ID WP_002892050.1
Coordinates 4006312..4006530 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H7R06_RS19335 Protein ID WP_002892066.1
Coordinates 4005911..4006285 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R06_RS19325 4001063..4002256 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H7R06_RS19330 4002279..4005425 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
H7R06_RS19335 4005911..4006285 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H7R06_RS19340 4006312..4006530 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H7R06_RS19345 4006689..4007255 + 567 WP_002892030.1 maltose O-acetyltransferase -
H7R06_RS19350 4007227..4007367 - 141 WP_004147370.1 hypothetical protein -
H7R06_RS19355 4007388..4007858 + 471 WP_002892026.1 YlaC family protein -
H7R06_RS19360 4007833..4009284 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H7R06_RS19365 4009385..4010083 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
H7R06_RS19370 4010080..4010220 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H7R06_RS19375 4010220..4010483 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T33710 WP_002892050.1 NZ_AP021909:4006312-4006530 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T33710 NZ_AP021909:4006312-4006530 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT33710 WP_002892066.1 NZ_AP021909:4005911-4006285 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT33710 NZ_AP021909:4005911-4006285 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References