Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5568298..5568926 Replicon chromosome
Accession NZ_AP021904
Organism Pseudomonas sp. Ost2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KI243_RS24490 Protein ID WP_177063736.1
Coordinates 5568298..5568696 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KI243_RS24495 Protein ID WP_177063735.1
Coordinates 5568696..5568926 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI243_RS24465 (PHLH7_48360) 5563685..5564308 + 624 WP_017124598.1 type II secretion system protein GspM -
KI243_RS24470 (PHLH7_48370) 5564305..5564805 + 501 WP_212809996.1 general secretion pathway protein GspN -
KI243_RS24475 (PHLH7_48380) 5564861..5567146 + 2286 WP_212809997.1 type II secretion system secretin GspD -
KI243_RS24480 (PHLH7_48390) 5567268..5567723 + 456 WP_017124600.1 glucosaminidase domain-containing protein -
KI243_RS24485 (PHLH7_48400) 5567717..5568187 + 471 WP_017124601.1 hypothetical protein -
KI243_RS24490 (PHLH7_48410) 5568298..5568696 - 399 WP_177063736.1 tRNA(fMet)-specific endonuclease VapC Toxin
KI243_RS24495 5568696..5568926 - 231 WP_177063735.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KI243_RS24500 (PHLH7_48420) 5569385..5569978 + 594 WP_177108576.1 hypothetical protein -
KI243_RS24505 (PHLH7_48430) 5570138..5570290 + 153 WP_177063828.1 hypothetical protein -
KI243_RS24510 5570558..5571244 - 687 Protein_4859 transposase -
KI243_RS24515 5571345..5572379 + 1035 Protein_4860 IS481 family transposase -
KI243_RS24520 5572446..5572970 - 525 WP_177055351.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14697.92 Da        Isoelectric Point: 7.4346

>T33689 WP_177063736.1 NZ_AP021904:c5568696-5568298 [Pseudomonas sp. Ost2]
MLKFMLDTNICIFTIKNKPQHVREAFKAHHGQLCISTVTLMELIYGAEKSSNPGRNLADVEGFAARLDVLKYDQDAAAHT
GQLRAELAKVGTPIGPYDHMIAGHARSQGLILVTNNLREFDRVPGLRVEDWV

Download         Length: 399 bp

>T33689 NZ_AP021904:c5568696-5568298 [Pseudomonas sp. Ost2]
ATGCTCAAATTCATGCTCGATACCAACATTTGCATCTTCACGATAAAGAACAAACCCCAGCATGTTCGCGAAGCGTTCAA
AGCTCACCATGGCCAGCTGTGCATCAGCACCGTGACTTTGATGGAACTCATCTATGGAGCGGAAAAATCTTCGAACCCAG
GACGAAACCTGGCCGACGTAGAGGGCTTTGCAGCACGACTGGATGTCTTGAAATACGACCAGGATGCGGCGGCGCATACA
GGTCAACTCCGTGCGGAGCTGGCTAAGGTTGGCACTCCGATTGGCCCTTACGATCACATGATTGCCGGGCACGCTCGTTC
GCAAGGTTTGATTTTGGTAACAAACAATCTACGCGAGTTTGACCGAGTGCCTGGTCTGCGCGTCGAAGACTGGGTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8498.38 Da        Isoelectric Point: 4.2821

>AT33689 WP_177063735.1 NZ_AP021904:c5568926-5568696 [Pseudomonas sp. Ost2]
MEQGSVFQSNRSQAVRLPKAAALPDDVKRVDIVAIGRTRIITPAGESWDSWFDGEGVTDDFMTAREQPAEQERESF

Download         Length: 231 bp

>AT33689 NZ_AP021904:c5568926-5568696 [Pseudomonas sp. Ost2]
ATGGAACAAGGCTCGGTATTTCAAAGCAATCGTAGTCAGGCCGTGCGCTTGCCAAAGGCTGCCGCGCTTCCTGATGACGT
CAAGCGCGTCGATATTGTTGCAATCGGCAGAACCCGAATCATCACCCCCGCGGGTGAGTCCTGGGATAGCTGGTTTGACG
GTGAAGGTGTAACGGATGATTTTATGACGGCTCGTGAGCAGCCAGCCGAGCAAGAGCGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References