33686

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4855956..4856515 Replicon chromosome
Accession NZ_AP021904
Organism Pseudomonas sp. Ost2

Toxin (Protein)


Gene name parE Uniprot ID A0A7Y7XWQ0
Locus tag KI243_RS21220 Protein ID WP_042936135.1
Coordinates 4856222..4856515 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7Y7XW57
Locus tag KI243_RS21215 Protein ID WP_017127942.1
Coordinates 4855956..4856234 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI243_RS21180 (PHLH7_41870) 4851162..4851743 + 582 WP_042936136.1 RNA polymerase sigma factor -
KI243_RS21185 (PHLH7_41880) 4851740..4852177 + 438 WP_177108795.1 hypothetical protein -
KI243_RS21190 (PHLH7_41890) 4852174..4852671 + 498 WP_017127947.1 periplasmic heavy metal sensor -
KI243_RS21195 (PHLH7_41900) 4852814..4853758 - 945 Protein_4206 chitinase -
KI243_RS21200 (PHLH7_41910) 4853864..4854499 - 636 WP_177063762.1 lytic polysaccharide monooxygenase -
KI243_RS21205 (PHLH7_41920) 4855159..4855479 + 321 WP_017127944.1 DUF3077 domain-containing protein -
KI243_RS21210 (PHLH7_41930) 4855525..4855782 - 258 WP_017127943.1 hypothetical protein -
KI243_RS21215 (PHLH7_41940) 4855956..4856234 + 279 WP_017127942.1 CopG family ribbon-helix-helix protein Antitoxin
KI243_RS21220 (PHLH7_41950) 4856222..4856515 + 294 WP_042936135.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI243_RS21225 (PHLH7_41960) 4856724..4858100 + 1377 WP_212809879.1 MFS transporter -
KI243_RS21230 (PHLH7_41970) 4858380..4859129 + 750 WP_177086807.1 glucose 1-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10991.64 Da        Isoelectric Point: 8.5277

>T33686 WP_042936135.1 NZ_AP021904:4856222-4856515 [Pseudomonas sp. Ost2]
MPRMIFAPAAIRDIQRLREFLRPKNADAAKRAGEAIIQGVRLLAAQPQIGRLVDDLPDEYREWLIDFGDSGYVARYRIDL
DTVTILTVRHQKEAGSA

Download         Length: 294 bp

>T33686 NZ_AP021904:4856222-4856515 [Pseudomonas sp. Ost2]
ATGCCACGAATGATCTTCGCCCCCGCCGCCATCCGGGATATTCAACGGCTACGGGAGTTTCTTCGCCCAAAGAATGCCGA
TGCGGCGAAACGCGCGGGTGAAGCGATCATCCAGGGTGTGCGGCTACTGGCAGCGCAGCCGCAGATCGGCAGACTGGTGG
ATGACCTGCCCGATGAGTACCGGGAATGGTTGATTGATTTTGGAGACAGCGGCTATGTAGCGCGCTATCGAATTGATCTC
GATACCGTCACGATCCTGACTGTTCGACACCAGAAAGAAGCGGGGTCTGCATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10775.97 Da        Isoelectric Point: 4.9477

>AT33686 WP_017127942.1 NZ_AP021904:4855956-4856234 [Pseudomonas sp. Ost2]
MATPTSIKLDDELKGRVQHLADARRRTSHWIMREAIAQYVEREEKRETFRQETLQAWEEFQATGLHATAEDVEKWLSSWG
TENELPAPPCHE

Download         Length: 279 bp

>AT33686 NZ_AP021904:4855956-4856234 [Pseudomonas sp. Ost2]
ATGGCAACCCCAACCTCCATCAAGCTTGATGATGAGCTGAAAGGACGCGTGCAGCATCTGGCCGATGCTCGCCGCCGTAC
TTCGCACTGGATCATGCGTGAGGCTATCGCACAGTACGTCGAGCGCGAAGAAAAACGTGAAACGTTCCGACAGGAGACGC
TGCAAGCCTGGGAAGAATTTCAAGCCACCGGACTGCACGCGACGGCCGAAGATGTCGAGAAATGGCTGTCGAGTTGGGGA
ACTGAGAACGAGCTACCTGCACCTCCATGCCACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y7XWQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y7XW57

References