Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1892958..1893574 Replicon chromosome
Accession NZ_AP021903
Organism Pseudomonas sp. Seg1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KI231_RS08445 Protein ID WP_213027965.1
Coordinates 1892958..1893170 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KI231_RS08450 Protein ID WP_213027966.1
Coordinates 1893170..1893574 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI231_RS08420 (PHLH6_16690) 1888127..1890115 + 1989 WP_213027964.1 heme lyase CcmF/NrfE family subunit -
KI231_RS08425 (PHLH6_16700) 1890112..1890648 + 537 WP_099758373.1 DsbE family thiol:disulfide interchange protein -
KI231_RS08430 (PHLH6_16710) 1890645..1891115 + 471 WP_103306826.1 cytochrome c-type biogenesis protein CcmH -
KI231_RS08435 (PHLH6_16720) 1891112..1892314 + 1203 WP_103306825.1 c-type cytochrome biogenesis protein CcmI -
KI231_RS08440 (PHLH6_16730) 1892346..1892750 + 405 WP_103306824.1 hypothetical protein -
KI231_RS08445 (PHLH6_16740) 1892958..1893170 + 213 WP_213027965.1 type II toxin-antitoxin system HicA family toxin Toxin
KI231_RS08450 (PHLH6_16750) 1893170..1893574 + 405 WP_213027966.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KI231_RS08455 (PHLH6_16760) 1893643..1894830 - 1188 WP_213027967.1 MFS transporter -
KI231_RS08460 (PHLH6_16770) 1895074..1895694 + 621 WP_213027968.1 DUF5666 domain-containing protein -
KI231_RS08465 (PHLH6_16780) 1895935..1896933 - 999 WP_213027969.1 sulfate ABC transporter substrate-binding protein -
KI231_RS08470 (PHLH6_16790) 1897037..1897861 - 825 WP_103306818.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7945.09 Da        Isoelectric Point: 10.0381

>T33680 WP_213027965.1 NZ_AP021903:1892958-1893170 [Pseudomonas sp. Seg1]
VQSRLLIKELEEAGWTLDGITGSHHIFRHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASFEGDP

Download         Length: 213 bp

>T33680 NZ_AP021903:1892958-1893170 [Pseudomonas sp. Seg1]
GTGCAAAGCAGGTTATTGATCAAGGAGCTGGAGGAGGCAGGATGGACGCTGGACGGGATTACCGGCAGCCATCACATCTT
CAGGCACCGTTACAACCCGTACACGATTCCCGTGCCTCATCCGAAAAAGGATTTACCGTTGGGGACGGTCAAAAGTATCA
GGAGGCGTGCCGGGCTGTACAACCCGCCAGCCAGTTTCGAAGGAGATCCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14860.82 Da        Isoelectric Point: 4.4032

>AT33680 WP_213027966.1 NZ_AP021903:1893170-1893574 [Pseudomonas sp. Seg1]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYNAAVEIAHIMLQEIAADGEHIPLPTSAAAHRNNPEFAEMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT33680 NZ_AP021903:1893170-1893574 [Pseudomonas sp. Seg1]
ATGCAATATCCCATCTGCATCGAGTGGGGTGATGAGAACACCGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCTGT
CACGGCGGGGGATAGCTTTGAAGATGCCTACAACGCAGCGGTTGAGATCGCACACATCATGCTGCAAGAGATCGCGGCGG
ACGGAGAGCACATTCCGTTGCCAACTTCTGCGGCGGCACATCGCAACAATCCGGAATTCGCCGAGATGGGTTGGGGCATG
CTGGAACTGGACATCTCGCCTTATCTGGGCAAGACCGAGAAGGTTAACGTGACGCTGCCCGGCTACGTGATCCAGCGAAT
TGATCGCTACGTGCGTGAGCACAACGTCAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAAAAACTGGTTCGGT
ATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References