Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1613889..1614512 Replicon chromosome
Accession NZ_AP021903
Organism Pseudomonas sp. Seg1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KI231_RS07120 Protein ID WP_103305578.1
Coordinates 1614333..1614512 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KI231_RS07115 Protein ID WP_103305577.1
Coordinates 1613889..1614296 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI231_RS07095 (PHLH6_14030) 1609541..1610719 + 1179 WP_213027825.1 DUF4236 domain-containing protein -
KI231_RS07100 (PHLH6_14040) 1610769..1612013 - 1245 WP_213027826.1 VWA domain-containing protein -
KI231_RS07105 (PHLH6_14050) 1612156..1612884 - 729 WP_213027827.1 class I SAM-dependent methyltransferase -
KI231_RS07110 (PHLH6_14060) 1613456..1613818 + 363 WP_213027828.1 DUF6124 family protein -
KI231_RS07115 (PHLH6_14070) 1613889..1614296 - 408 WP_103305577.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KI231_RS07120 (PHLH6_14080) 1614333..1614512 - 180 WP_103305578.1 type II toxin-antitoxin system HicA family toxin Toxin
KI231_RS07125 (PHLH6_14090) 1614873..1615391 + 519 WP_213027829.1 hypothetical protein -
KI231_RS07130 (PHLH6_14100) 1615411..1615593 - 183 WP_213027830.1 hypothetical protein -
KI231_RS07140 (PHLH6_14110) 1616079..1616963 - 885 WP_213027831.1 alpha/beta hydrolase -
KI231_RS07145 (PHLH6_14120) 1617280..1617972 - 693 WP_213027832.1 pseudouridine synthase -
KI231_RS07150 (PHLH6_14130) 1618006..1618224 - 219 WP_283246375.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6642.94 Da        Isoelectric Point: 11.1923

>T33679 WP_103305578.1 NZ_AP021903:c1614512-1614333 [Pseudomonas sp. Seg1]
VNSRFLIGQLVADGWYLVRIKGSHHHFKHPTKPGLVAVPHPKKDLLKKTAISILQQPLL

Download         Length: 180 bp

>T33679 NZ_AP021903:c1614512-1614333 [Pseudomonas sp. Seg1]
GTGAATAGCCGTTTTTTAATCGGCCAACTCGTCGCAGACGGTTGGTATCTGGTACGGATCAAAGGAAGTCACCATCACTT
CAAGCATCCGACCAAACCTGGACTGGTCGCCGTGCCACATCCGAAAAAGGATCTGCTGAAGAAAACGGCCATCAGTATTT
TGCAGCAGCCGCTGCTTTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14512.56 Da        Isoelectric Point: 4.7142

>AT33679 WP_103305577.1 NZ_AP021903:c1614296-1613889 [Pseudomonas sp. Seg1]
MLYPIAISIGDDQHAWGVEVPDIPGCFSAGEDLDDAVAMAREAIEGHFEILADDGAPIPAASKLSLHVANPKYTGCAWAV
VDIDVLKYLGKAQKLNITLPGHLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Download         Length: 408 bp

>AT33679 NZ_AP021903:c1614296-1613889 [Pseudomonas sp. Seg1]
ATGCTCTACCCGATTGCGATTTCAATTGGCGATGACCAACACGCCTGGGGTGTAGAAGTCCCGGACATTCCTGGATGCTT
TTCCGCTGGAGAGGATCTGGACGATGCCGTCGCCATGGCTCGCGAAGCCATCGAAGGTCATTTCGAGATTCTCGCGGACG
ACGGCGCTCCCATTCCAGCGGCCAGCAAGCTGAGCCTGCACGTGGCCAACCCGAAATACACCGGCTGTGCATGGGCCGTG
GTGGATATCGATGTGCTCAAGTATTTGGGCAAAGCCCAAAAACTCAACATCACCCTGCCGGGCCACTTGCTCAACCGCAT
TGATGAGTATGTGTTGCATCACCCGGAAGAGAAAAGCCGTTCCGGGTTTCTGGCTTCGGCAGCGTTGAAGGTGTTGCAGC
AGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References