Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-higA/VapC-HigA
Location 916880..917773 Replicon chromosome
Accession NZ_AP021903
Organism Pseudomonas sp. Seg1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KI231_RS03885 Protein ID WP_213027501.1
Coordinates 916880..917299 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI231_RS03890 Protein ID WP_213027502.1
Coordinates 917342..917773 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI231_RS03870 (PHLH6_07650) 913064..915022 + 1959 WP_213027499.1 DUF1302 domain-containing protein -
KI231_RS03875 (PHLH6_07660) 915172..916545 + 1374 WP_213027500.1 DUF1329 domain-containing protein -
KI231_RS03880 (PHLH6_07670) 916638..916883 + 246 WP_103303249.1 plasmid stabilization protein -
KI231_RS03885 (PHLH6_07680) 916880..917299 + 420 WP_213027501.1 type II toxin-antitoxin system VapC family toxin Toxin
KI231_RS03890 (PHLH6_07690) 917342..917773 + 432 WP_213027502.1 transcriptional regulator Antitoxin
KI231_RS03895 (PHLH6_07700) 917918..919837 - 1920 WP_213027503.1 methyl-accepting chemotaxis protein -
KI231_RS03900 (PHLH6_07710) 920079..920750 + 672 WP_213027504.1 histidine phosphatase family protein -
KI231_RS03905 (PHLH6_07720) 920747..921565 + 819 WP_213027505.1 phosphatase PAP2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-138)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15192.54 Da        Isoelectric Point: 5.5998

>T33678 WP_213027501.1 NZ_AP021903:916880-917299 [Pseudomonas sp. Seg1]
MIVLDTNVLSEFMRVKPDDRVLVWVDAQPAMDLAVSAVTVAEILHGIARLPSGKRKQKLEAHAMAMFEQDFAGRILPFDA
HAAVEYATLVAECESKGRAASMADAQIAAICRTHGVPIATRNVKDFEFSGVEVINPWQS

Download         Length: 420 bp

>T33678 NZ_AP021903:916880-917299 [Pseudomonas sp. Seg1]
ATGATCGTGCTCGATACCAACGTTCTTTCAGAGTTTATGCGTGTCAAGCCAGACGACCGGGTGCTTGTCTGGGTGGATGC
GCAGCCAGCGATGGATCTGGCAGTCAGCGCGGTGACAGTGGCAGAAATACTCCACGGCATCGCACGCCTGCCATCTGGCA
AGCGCAAACAAAAACTTGAGGCTCATGCCATGGCGATGTTCGAACAGGATTTTGCCGGACGCATTTTGCCGTTCGATGCG
CACGCCGCTGTCGAATACGCAACGCTAGTCGCGGAGTGCGAGTCAAAGGGTCGCGCGGCTTCGATGGCTGATGCGCAAAT
TGCTGCTATCTGCCGAACGCATGGTGTTCCCATAGCCACCCGTAACGTGAAGGATTTTGAGTTCAGTGGTGTCGAGGTGA
TAAATCCTTGGCAGAGCTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16078.40 Da        Isoelectric Point: 4.8430

>AT33678 WP_213027502.1 NZ_AP021903:917342-917773 [Pseudomonas sp. Seg1]
MKRKKVGTSRLDSFMVDDFPVLAGLADPIKNDGELQVRMALIDEFYSHADSEDHAAARFAELVADRVYEYEAETVLIPYS
SQSEALAFLILERGVKQKDLSEIATQSAVSEILNNKRKMTVAQIKGFAEFFKVPVEFFMHGVV

Download         Length: 432 bp

>AT33678 NZ_AP021903:917342-917773 [Pseudomonas sp. Seg1]
ATGAAGCGTAAAAAGGTTGGAACGAGCAGGTTGGACTCCTTCATGGTTGATGATTTTCCCGTTCTTGCCGGTCTAGCGGA
CCCGATAAAAAACGACGGTGAGTTGCAAGTGCGAATGGCCCTGATTGATGAGTTTTACTCGCATGCTGACAGTGAAGATC
ACGCAGCGGCGCGGTTTGCGGAATTGGTTGCTGATCGGGTGTATGAGTACGAGGCTGAAACGGTTTTGATTCCTTACTCA
TCCCAATCAGAAGCGCTGGCGTTTCTGATTTTGGAAAGAGGAGTCAAACAGAAGGATTTGTCTGAGATCGCAACTCAGAG
TGCTGTTTCAGAGATATTGAATAACAAGCGAAAAATGACGGTTGCTCAAATCAAAGGTTTTGCCGAATTCTTTAAAGTGC
CGGTTGAGTTCTTCATGCATGGCGTGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References