Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 371884..372521 Replicon chromosome
Accession NZ_AP021903
Organism Pseudomonas sp. Seg1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KI231_RS01585 Protein ID WP_103304179.1
Coordinates 371884..372291 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KI231_RS01590 Protein ID WP_103304180.1
Coordinates 372291..372521 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI231_RS01565 (PHLH6_03110) 367565..368257 - 693 WP_095047149.1 ABC transporter permease -
KI231_RS01570 (PHLH6_03120) 368333..369082 - 750 WP_103304176.1 ABC transporter substrate-binding protein -
KI231_RS01575 (PHLH6_03130) 369096..369869 - 774 WP_103304177.1 ABC transporter ATP-binding protein -
KI231_RS01580 (PHLH6_03140) 370422..371813 + 1392 WP_213027253.1 GABA permease -
KI231_RS01585 (PHLH6_03150) 371884..372291 - 408 WP_103304179.1 tRNA(fMet)-specific endonuclease VapC Toxin
KI231_RS01590 (PHLH6_03160) 372291..372521 - 231 WP_103304180.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KI231_RS01595 (PHLH6_03170) 372686..373138 - 453 WP_213027254.1 hypothetical protein -
KI231_RS01600 (PHLH6_03180) 373145..373558 - 414 WP_123449407.1 hypothetical protein -
KI231_RS01605 (PHLH6_03190) 373588..374499 - 912 WP_249412148.1 alpha/beta fold hydrolase -
KI231_RS01610 (PHLH6_03200) 374630..375688 - 1059 WP_213027255.1 PDDEXK nuclease domain-containing protein -
KI231_RS01615 (PHLH6_03210) 375950..376399 + 450 WP_103304185.1 hypothetical protein -
KI231_RS01620 (PHLH6_03220) 376396..376743 - 348 WP_103304186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14940.38 Da        Isoelectric Point: 6.7119

>T33677 WP_103304179.1 NZ_AP021903:c372291-371884 [Pseudomonas sp. Seg1]
MIKYMLDTNICIFTIKNKPQIVREAFNRHSGQLCISAITLMELIYGAEKSAAPEKNLAVVEGFVARLEILPFDNDAAAQT
GMIRSELAKAGTPIGPYDQMIAGHARSLGLIVVTNNVREFERVSGLRIEDWVHPV

Download         Length: 408 bp

>T33677 NZ_AP021903:c372291-371884 [Pseudomonas sp. Seg1]
ATGATCAAATACATGCTGGATACCAACATCTGCATCTTCACCATCAAGAACAAACCACAAATTGTCCGGGAAGCTTTCAA
TCGACATTCCGGGCAGTTGTGCATCAGCGCTATCACGCTCATGGAGCTTATTTACGGTGCTGAAAAGTCCGCGGCCCCAG
AAAAGAATCTAGCGGTTGTCGAAGGATTCGTTGCGCGATTGGAAATCTTGCCTTTCGATAATGACGCAGCAGCACAGACC
GGGATGATTCGATCTGAACTTGCGAAAGCGGGAACACCCATTGGACCGTACGACCAAATGATCGCAGGCCACGCACGGTC
GCTTGGACTTATCGTAGTCACGAACAATGTGCGGGAATTTGAACGTGTTTCCGGATTGCGTATTGAGGATTGGGTTCATC
CCGTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8573.61 Da        Isoelectric Point: 4.3719

>AT33677 WP_103304180.1 NZ_AP021903:c372521-372291 [Pseudomonas sp. Seg1]
MEQTTIFMSNRSQAVRLPKAVAMPGDVKRVEIIAIGRTRVITPAGESWDSWFDGDSVTPDFMADREQPADQERESF

Download         Length: 231 bp

>AT33677 NZ_AP021903:c372521-372291 [Pseudomonas sp. Seg1]
ATGGAACAGACCACAATTTTCATGAGCAATAGAAGTCAGGCAGTTCGACTGCCAAAGGCAGTTGCGATGCCCGGCGACGT
TAAACGAGTGGAAATCATCGCGATTGGCAGAACACGCGTCATTACGCCTGCTGGAGAAAGCTGGGATAGCTGGTTTGATG
GCGACAGCGTCACCCCTGATTTCATGGCTGACCGTGAGCAACCCGCTGATCAGGAGCGCGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References