Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4494066..4494687 Replicon chromosome
Accession NZ_AP021901
Organism Pseudomonas sp. St316

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KI237_RS19850 Protein ID WP_212796700.1
Coordinates 4494066..4494248 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KI237_RS19855 Protein ID WP_212796701.1
Coordinates 4494286..4494687 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI237_RS19820 (PHLH4_39590) 4489447..4490802 - 1356 WP_212796695.1 DUF1073 domain-containing protein -
KI237_RS19825 (PHLH4_39600) 4490799..4492064 - 1266 WP_249410646.1 terminase family protein -
KI237_RS19830 (PHLH4_39610) 4492042..4492575 - 534 WP_212796697.1 DUF2280 domain-containing protein -
KI237_RS19835 (PHLH4_39620) 4492607..4493230 - 624 WP_212796698.1 putative metallopeptidase -
KI237_RS19840 (PHLH4_39630) 4493285..4493629 - 345 WP_212796699.1 hypothetical protein -
KI237_RS19845 (PHLH4_39640) 4493626..4493955 - 330 WP_028236772.1 hypothetical protein -
KI237_RS19850 4494066..4494248 + 183 WP_212796700.1 type II toxin-antitoxin system HicA family toxin Toxin
KI237_RS19855 (PHLH4_39650) 4494286..4494687 + 402 WP_212796701.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KI237_RS19860 (PHLH4_39660) 4495028..4495573 - 546 WP_212796702.1 hypothetical protein -
KI237_RS19865 (PHLH4_39670) 4495570..4496226 - 657 WP_212796703.1 recombination protein NinG -
KI237_RS19870 (PHLH4_39680) 4496223..4496444 - 222 WP_212796704.1 hypothetical protein -
KI237_RS19875 (PHLH4_39690) 4496441..4496908 - 468 WP_212796705.1 recombination protein NinB -
KI237_RS19880 (PHLH4_39700) 4496905..4497108 - 204 WP_212796706.1 hypothetical protein -
KI237_RS19885 (PHLH4_39710) 4497105..4497614 - 510 WP_212796707.1 hypothetical protein -
KI237_RS19890 (PHLH4_39720) 4497611..4498396 - 786 WP_212796708.1 replication protein P -
KI237_RS19895 (PHLH4_39730) 4498393..4499178 - 786 WP_212796709.1 DnaT-like ssDNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4383570..4520362 136792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6710.95 Da        Isoelectric Point: 11.3688

>T33672 WP_212796700.1 NZ_AP021901:4494066-4494248 [Pseudomonas sp. St316]
VQSRQLIKELEAAGWVLDRVTGSHHMFKHPNRPQTVPVPHPKKDLPIGTVRAIKKLAGLI

Download         Length: 183 bp

>T33672 NZ_AP021901:4494066-4494248 [Pseudomonas sp. St316]
GTGCAAAGCAGGCAGTTGATAAAGGAGCTTGAAGCCGCTGGATGGGTTCTAGATCGAGTAACCGGAAGCCACCACATGTT
CAAGCATCCAAACAGACCCCAAACAGTTCCCGTGCCACACCCCAAGAAAGACCTACCAATCGGAACTGTAAGGGCCATCA
AGAAACTAGCCGGGTTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.47 Da        Isoelectric Point: 4.2692

>AT33672 WP_212796701.1 NZ_AP021901:4494286-4494687 [Pseudomonas sp. St316]
MQYPICIEWGDENTATGIQIPDIPGAITAGDTFEEAYSAAVEIANIMLEEIASSGAPIPMPSPTAKHRSNPEFSDMGWGM
LEVDITPYLGKTEKVNVTLPGFVVQQIDRFVRDHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT33672 NZ_AP021901:4494286-4494687 [Pseudomonas sp. St316]
ATGCAATACCCAATCTGCATCGAATGGGGCGACGAAAACACCGCCACCGGCATTCAGATTCCTGACATCCCCGGTGCAAT
TACAGCCGGCGACACATTCGAGGAGGCGTACAGCGCTGCCGTCGAGATCGCCAACATCATGCTTGAGGAGATCGCATCAA
GCGGCGCACCTATTCCAATGCCATCTCCAACCGCCAAACACCGGAGCAATCCAGAGTTTTCCGATATGGGCTGGGGCATG
CTGGAGGTGGACATCACGCCATACCTGGGGAAAACCGAAAAGGTTAACGTGACACTGCCTGGCTTTGTTGTGCAGCAGAT
CGACCGCTTCGTCCGCGACCACAACATCAAAAGTCGCTCATCTTTCCTGGCCGATGCAGCCATGGAAAAGCTGGGACGGT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References