Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2290075..2290601 Replicon chromosome
Accession NZ_AP021894
Organism Escherichia coli strain 2018-10-1CC

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HRR23_RS11125 Protein ID WP_000323025.1
Coordinates 2290314..2290601 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HRR23_RS11120 Protein ID WP_000534858.1
Coordinates 2290075..2290314 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR23_RS11090 2285118..2285382 + 265 Protein_2169 hypothetical protein -
HRR23_RS11105 2287433..2288773 + 1341 WP_000589013.1 ISNCY family transposase -
HRR23_RS11110 2289210..2289542 - 333 WP_001301033.1 protein FlxA -
HRR23_RS11115 2289745..2290050 - 306 WP_071593935.1 hypothetical protein -
HRR23_RS11120 2290075..2290314 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HRR23_RS11125 2290314..2290601 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HRR23_RS11130 2290673..2290828 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
HRR23_RS11135 2291045..2291296 + 252 WP_001463433.1 hypothetical protein -
HRR23_RS11140 2291363..2291641 + 279 WP_172410193.1 hypothetical protein -
HRR23_RS11145 2291643..2292692 + 1050 WP_001515372.1 DUF968 domain-containing protein -
HRR23_RS11150 2292710..2293087 + 378 WP_001204787.1 antitermination protein -
HRR23_RS11155 2293243..2293767 - 525 WP_000780584.1 lipocalin family protein -
HRR23_RS11160 2293877..2294574 + 698 Protein_2182 IS1 family transposase -
HRR23_RS11165 2294721..2295434 + 714 WP_001146314.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2268267..2310091 41824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T33624 WP_000323025.1 NZ_AP021894:2290314-2290601 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T33624 NZ_AP021894:2290314-2290601 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT33624 WP_000534858.1 NZ_AP021894:2290075-2290314 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT33624 NZ_AP021894:2290075-2290314 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References