Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 948045..948628 Replicon chromosome
Accession NZ_AP021891
Organism Escherichia coli strain 2017.01.04CC

Toxin (Protein)


Gene name mazF Uniprot ID S1EZP4
Locus tag VEGS_RS04525 Protein ID WP_000254738.1
Coordinates 948293..948628 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1V2T5M9
Locus tag VEGS_RS04520 Protein ID WP_000581941.1
Coordinates 948045..948293 (+) Length 83 a.a.

Genomic Context

VEGS_RS04510VEGS_RS04515VEGS_RS04520VEGS_RS04525VEGS_RS04530VEGS_RS04535VEGS_RS04540
Location: 944384..945685 (1302 bp)
Type: Others
Protein ID: WP_023281448.1
Location: 945733..947967 (2235 bp)
Type: Others
Protein ID: WP_000226815.1
Location: 948045..948293 (249 bp)
Type: Antitoxin
Protein ID: WP_000581941.1
Location: 948293..948628 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1
Location: 948699..949490 (792 bp)
Type: Others
Protein ID: WP_001071648.1
Location: 949718..951355 (1638 bp)
Type: Others
Protein ID: WP_000210878.1
Location: 951443..952741 (1299 bp)
Type: Others
Protein ID: WP_000036723.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VEGS_RS04510944384..945685+1302WP_023281448.123S rRNA (uracil(1939)-C(5))-methyltransferase RlmD-
VEGS_RS04515945733..947967+2235WP_000226815.1GTP pyrophosphokinase-
VEGS_RS04520948045..948293+249WP_000581941.1type II toxin-antitoxin system antitoxin MazEAntitoxin
VEGS_RS04525948293..948628+336WP_000254738.1endoribonuclease MazFToxin
VEGS_RS04530948699..949490+792WP_001071648.1nucleoside triphosphate pyrophosphohydrolase-
VEGS_RS04535949718..951355+1638WP_000210878.1CTP synthase (glutamine hydrolyzing)-
VEGS_RS04540951443..952741+1299WP_000036723.1phosphopyruvate hydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12098.04 Da        Isoelectric Point: 8.2618

>T33549 WP_000254738.1 NZ_AP021891:948293-948628 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

>T33549 NZ_AP021891:948293-948628 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9385.76 Da        Isoelectric Point: 4.4665

>AT33549 WP_000581941.1 NZ_AP021891:948045-948293 [Escherichia coli]
MIHSSVKRWGNSPAVRIPTTLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp

>AT33549 NZ_AP021891:948045-948293 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGACTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB1UB4
PDB5CQX
PDB5CK9
PDB5CKH
PDB5CO7
PDB3NFC
PDB5CR2
PDB5CKB
PDB5CQY
PDB5CKD
PDB5CKE
PDB5CKF

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1V2T5M9

References