Detailed information of TA system TA033517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1375864..1376450
• Replicon: chromosome
• Accession: NZ_AP021889
• Organism: Thiosulfatimonas sediminis strain aks77

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HRR27_RS06345
• Protein ID: WP_173271979.1
• Coordinates: 1376196..1376450 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HRR27_RS06340
• Protein ID: WP_173271977.1
• Coordinates: 1375864..1376199 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRR27_RS06290	1371157..1371450	+	294	WP_173271959.1	hypothetical protein	-
HRR27_RS06295	1371450..1371716	+	267	WP_173271961.1	hypothetical protein	-
HRR27_RS06300	1371716..1372216	+	501	WP_173271963.1	hypothetical protein	-
HRR27_RS06305	1372198..1372470	+	273	WP_173271965.1	PriCT-2 domain-containing protein	-
HRR27_RS06310	1372474..1372893	+	420	WP_173271966.1	hypothetical protein	-
HRR27_RS06315	1373249..1373770	+	522	WP_173271968.1	single-stranded DNA-binding protein	-
HRR27_RS06320	1373782..1374570	+	789	WP_173271970.1	hypothetical protein	-
HRR27_RS06325	1374612..1375115	+	504	WP_173271972.1	siphovirus Gp157 family protein	-
HRR27_RS06330	1375128..1375388	+	261	WP_173271974.1	hypothetical protein	-
HRR27_RS06335	1375378..1375746	+	369	WP_173271976.1	RusA family crossover junction endodeoxyribonuclease	-
HRR27_RS06340	1375864..1376199	-	336	WP_173271977.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HRR27_RS06345	1376196..1376450	-	255	WP_173271979.1	type II toxin-antitoxin system HicA family toxin	Toxin
HRR27_RS06350	1376726..1376938	-	213	WP_173271981.1	hypothetical protein	-
HRR27_RS06355	1377520..1378146	+	627	WP_173271983.1	thioredoxin domain-containing protein	-
HRR27_RS06360	1378417..1378605	-	189	WP_173271985.1	hypothetical protein	-
HRR27_RS06365	1378714..1380426	-	1713	WP_173271987.1	PAS domain S-box protein	-
HRR27_RS06370	1380677..1380922	-	246	WP_173271989.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9565.12 Da
• Isoelectric Point: 10.6854

>T33517 WP_173271979.1 NZ_AP021889:c1376450-1376196 [Thiosulfatimonas sediminis]
MKAKHQKTIELIFKRPVSANIKWKDIEVLFIALGGEVEEREGSRVGVFLFNEVRIFHRPHPSPNTDKGAVASVRKWLESN
GVKP

Nucleotide

• Length: 255 bp

>T33517 NZ_AP021889:c1376450-1376196 [Thiosulfatimonas sediminis]
ATGAAAGCAAAACACCAAAAAACCATTGAATTAATTTTTAAACGCCCTGTTAGCGCCAATATCAAGTGGAAGGATATTGA
AGTCCTTTTTATTGCGCTTGGGGGTGAAGTTGAAGAACGTGAAGGCTCTCGGGTTGGCGTGTTTCTGTTTAATGAAGTGC
GTATTTTCCACCGGCCCCATCCGTCACCTAATACGGATAAGGGCGCGGTTGCCAGTGTTAGAAAATGGCTTGAATCAAAC
GGGGTGAAACCATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12449.15 Da
• Isoelectric Point: 5.1976

>AT33517 WP_173271977.1 NZ_AP021889:c1376199-1375864 [Thiosulfatimonas sediminis]
MKNILEIDGYKAHIDYDSDIELFRGEFIGLNGGADFYASDIEGLKTEAKQSLTAFLDMCKEKGIEPKKQYSGRFNVRIAS
DLHAKIAAIAVAENKSLNQWIEENLSKVVLH

Nucleotide

• Length: 336 bp

>AT33517 NZ_AP021889:c1376199-1375864 [Thiosulfatimonas sediminis]
ATGAAGAATATTTTAGAAATCGACGGCTACAAAGCCCATATTGATTACGACTCAGATATTGAACTATTCCGCGGGGAATT
TATCGGCCTGAATGGGGGGGCGGACTTTTACGCCTCGGATATTGAGGGTTTAAAAACTGAGGCTAAACAGTCCCTAACCG
CTTTTCTGGATATGTGCAAAGAAAAAGGCATTGAGCCTAAGAAACAGTATTCAGGGCGTTTTAACGTGCGCATTGCATCT
GATCTGCACGCGAAAATAGCCGCTATTGCCGTGGCTGAAAACAAAAGCCTTAACCAGTGGATTGAGGAAAACCTGTCCAA
GGTCGTTTTGCATTAA