Detailed information of TA system TA033515

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2602030..2602666
• Replicon: chromosome
• Accession: NZ_AP021888
• Organism: Thiosulfativibrio zosterae strain AkT22

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THMIRH_RS11890
• Protein ID: WP_173292303.1
• Coordinates: 2602265..2602666 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: THMIRH_RS11885
• Protein ID: WP_194240842.1
• Coordinates: 2602030..2602272 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THMIRH_RS11865	2597204..2598181	-	978	WP_173292299.1	ABC transporter substrate-binding protein	-
THMIRH_RS11870	2598316..2598522	+	207	WP_173292300.1	hypothetical protein	-
THMIRH_RS11875	2598600..2601434	+	2835	WP_173292301.1	EAL domain-containing protein	-
THMIRH_RS11880	2601444..2601920	+	477	WP_173292302.1	hypothetical protein	-
THMIRH_RS11885	2602030..2602272	+	243	WP_194240842.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
THMIRH_RS11890	2602265..2602666	+	402	WP_173292303.1	type II toxin-antitoxin system VapC family toxin	Toxin
THMIRH_RS11895	2602831..2603352	+	522	WP_173292304.1	transposase	-
THMIRH_RS11900	2603626..2604228	-	603	WP_173292305.1	LPP20 family lipoprotein	-
THMIRH_RS11905	2604641..2607346	+	2706	WP_173292306.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14992.32 Da
• Isoelectric Point: 7.4335

>T33515 WP_173292303.1 NZ_AP021888:2602265-2602666 [Thiosulfativibrio zosterae]
MIKYLLDTNICIYVIKRRPIEVLQKFNEAAGHIAISSITLAELLHGVEKSQHLAKNLKAVEDFCSRLDVLNYDDKAASHY
GEIRADLEKKGKPIGVNDLHIAGHARSMGAILVSNNLKEFERVEGLRLQNWID

Nucleotide

• Length: 402 bp

>T33515 NZ_AP021888:2602265-2602666 [Thiosulfativibrio zosterae]
ATGATTAAATATTTATTGGACACCAACATATGTATTTATGTCATCAAACGCCGACCCATAGAAGTTTTACAAAAATTTAA
TGAGGCGGCAGGTCATATCGCCATTTCCTCTATTACACTTGCTGAACTCTTGCATGGCGTTGAAAAAAGCCAACATCTTG
CCAAAAACCTCAAAGCAGTTGAAGATTTTTGCAGTCGATTAGATGTGCTCAACTATGACGACAAAGCTGCTTCGCATTAT
GGTGAGATTCGGGCAGATTTAGAGAAAAAAGGCAAACCGATTGGTGTTAATGATTTGCATATAGCTGGTCATGCCAGAAG
TATGGGTGCAATTCTTGTGAGTAATAACCTAAAAGAGTTTGAGCGAGTTGAAGGCTTACGGCTTCAAAACTGGATTGACT
AA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9070.23 Da
• Isoelectric Point: 4.7405

>AT33515 WP_194240842.1 NZ_AP021888:2602030-2602272 [Thiosulfativibrio zosterae]
MINATVFENNKTQAVRLPVAVRFPSSVKKVVVRAVGKERVICPLENTWDSFFLNPETAVSDDFLNERAQQTESPREAFDD

Nucleotide

• Length: 243 bp

>AT33515 NZ_AP021888:2602030-2602272 [Thiosulfativibrio zosterae]
ATGATTAATGCAACCGTTTTTGAAAATAATAAAACCCAAGCCGTTCGCTTACCTGTTGCCGTGCGCTTTCCCAGCTCCGT
TAAAAAAGTGGTTGTGCGCGCAGTTGGTAAAGAACGCGTGATTTGCCCACTTGAAAACACTTGGGATAGTTTCTTTTTAA
ATCCAGAAACCGCTGTTTCAGATGATTTTTTGAATGAGCGTGCCCAACAAACCGAAAGCCCAAGAGAAGCTTTTGATGAT
TAA