Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 501981..502608 Replicon chromosome
Accession NZ_AP021887
Organism Streptococcus sp. 116-D4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag UKS_RS02675 Protein ID WP_156011722.1
Coordinates 502258..502608 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag UKS_RS02670 Protein ID WP_156011721.1
Coordinates 501981..502268 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UKS_RS02655 498893..499996 + 1104 WP_000241736.1 Gfo/Idh/MocA family oxidoreductase -
UKS_RS02660 500065..500982 + 918 WP_156011719.1 dihydrodipicolinate synthase family protein -
UKS_RS02665 501000..501884 + 885 WP_156011720.1 ROK family protein -
UKS_RS02670 501981..502268 + 288 WP_156011721.1 hypothetical protein Antitoxin
UKS_RS02675 502258..502608 + 351 WP_156011722.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
UKS_RS02680 502670..503521 - 852 WP_049494658.1 MurR/RpiR family transcriptional regulator -
UKS_RS02685 503713..505770 + 2058 WP_156011723.1 penicillin-binding protein PBP2B -
UKS_RS02690 505781..506377 + 597 WP_000966754.1 recombination mediator RecR -
UKS_RS02695 506552..507595 + 1044 WP_156011724.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13736.90 Da        Isoelectric Point: 9.8158

>T33512 WP_156011722.1 NZ_AP021887:502258-502608 [Streptococcus sp. 116-D4]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVASIRKDMNRLEIFPQAGFDADEKFGKKLDPRYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T33512 NZ_AP021887:502258-502608 [Streptococcus sp. 116-D4]
ATGGATTATAAAAAATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGATAAAATATATCAGTATATAGCAGA
GGAAATCGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCGAGTATCAGAAAAGATATGAATCGGCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGACCCTCGCTACCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACTAAGTCAAGATACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10829.20 Da        Isoelectric Point: 4.1285

>AT33512 WP_156011721.1 NZ_AP021887:501981-502268 [Streptococcus sp. 116-D4]
MAIANSNKIVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVAVTNEVDLLNEEELEKEYLFRQLQAEVQESYAKIEA
GSYLTDEDVVTRYGL

Download         Length: 288 bp

>AT33512 NZ_AP021887:501981-502268 [Streptococcus sp. 116-D4]
ATGGCTATAGCGAATTCAAATAAAATTGTGACCTTCCAAGCTAATAGAGAATTGGTAAATGATGCCATGGAGGTGTTAAA
AGAACAAAACCTCTCTCTTTCATCGGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTTA
ATGAAGAGGAATTAGAGAAGGAGTACTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGCTATGCCAAGATTGAGGCT
GGAAGTTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References