Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 111381..112005 Replicon chromosome
Accession NZ_AP021887
Organism Streptococcus sp. 116-D4

Toxin (Protein)


Gene name parE Uniprot ID A0A6H3SGD2
Locus tag UKS_RS00540 Protein ID WP_049494785.1
Coordinates 111658..112005 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6H3SHP6
Locus tag UKS_RS00535 Protein ID WP_049494786.1
Coordinates 111381..111668 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UKS_RS00500 106856..107320 - 465 Protein_90 hypothetical protein -
UKS_RS00510 107872..108309 - 438 WP_156011364.1 thiol-disulfide isomerase -
UKS_RS00515 108302..109141 - 840 WP_156011365.1 excalibur calcium-binding domain-containing protein -
UKS_RS00520 109326..109652 + 327 WP_156011366.1 helix-turn-helix transcriptional regulator -
UKS_RS00525 110053..110856 - 804 WP_140834014.1 hypothetical protein -
UKS_RS00535 111381..111668 + 288 WP_049494786.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
UKS_RS00540 111658..112005 + 348 WP_049494785.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
UKS_RS00545 112303..113053 + 751 Protein_97 hypothetical protein -
UKS_RS00550 113251..113400 - 150 WP_001265622.1 50S ribosomal protein L33 -
UKS_RS00555 113416..113598 - 183 WP_000290417.1 50S ribosomal protein L32 -
UKS_RS00560 113829..115532 + 1704 WP_156011367.1 dihydroxy-acid dehydratase -
UKS_RS00565 115593..115934 - 342 WP_049494775.1 metal-sulfur cluster assembly factor -
UKS_RS00575 116057..116911 + 855 WP_156011368.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-70)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13394.40 Da        Isoelectric Point: 6.7190

>T33511 WP_049494785.1 NZ_AP021887:111658-112005 [Streptococcus sp. 116-D4]
MEFNENVYSLIISETVQEQLRGIKDYISANYFSEQAGANTVKNILYGLKRLEVFPEAGFDADERVGVIIYPPHKTRCIIL
GDYLAFYHILEDRKAVFISDIIHSKQDYIRLFKKK

Download         Length: 348 bp

>T33511 NZ_AP021887:111658-112005 [Streptococcus sp. 116-D4]
TTGGAATTTAACGAGAACGTATATAGCCTTATTATCTCCGAAACGGTACAAGAACAGCTAAGAGGTATTAAAGATTATAT
CTCAGCTAACTACTTTTCAGAACAGGCAGGAGCAAACACAGTTAAGAATATTCTTTATGGTTTGAAGCGGCTTGAAGTTT
TTCCAGAAGCAGGATTTGATGCTGATGAAAGAGTAGGAGTTATTATATACCCACCCCACAAAACTCGATGCATCATTTTA
GGCGATTACCTAGCCTTCTATCATATTTTAGAGGACAGAAAAGCTGTCTTTATATCAGATATTATTCATAGCAAACAGGA
CTACATCCGCTTGTTCAAGAAAAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10864.30 Da        Isoelectric Point: 4.7119

>AT33511 WP_049494786.1 NZ_AP021887:111381-111668 [Streptococcus sp. 116-D4]
MNVLEKNTQVNFKTNKDLLEKAKAIITAQNLDMTASFNLFLEHIVENKALPFETQVDKEREELLSGLRAEIARSFDDLEH
GRTYSLDEVRANLGI

Download         Length: 288 bp

>AT33511 NZ_AP021887:111381-111668 [Streptococcus sp. 116-D4]
ATGAATGTTTTAGAAAAAAATACACAGGTAAACTTTAAGACTAACAAAGACTTGTTAGAGAAGGCTAAAGCTATTATCAC
AGCGCAAAATCTTGATATGACAGCTAGTTTTAACTTGTTTTTAGAACACATTGTAGAAAATAAAGCTTTGCCATTTGAAA
CTCAAGTAGATAAAGAAAGAGAAGAACTTCTATCAGGGTTGCGTGCTGAAATTGCCCGTAGCTTTGACGATTTAGAACAT
GGAAGAACTTACAGCCTTGATGAAGTGAGGGCTAACCTTGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H3SGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3SHP6

References