Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1060791..1061481 Replicon chromosome
Accession NZ_AP021884
Organism Sulfuriferula plumbiphila strain Gro7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GZH91_RS05665 Protein ID WP_147073959.1
Coordinates 1061056..1061481 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GZH91_RS05660 Protein ID WP_198415461.1
Coordinates 1060791..1061054 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH91_RS05645 1056278..1059772 + 3495 WP_147073953.1 hypothetical protein -
GZH91_RS05650 1059769..1060221 + 453 WP_147073955.1 type IV pilin protein -
GZH91_RS05655 1060343..1060778 - 436 Protein_1101 hypothetical protein -
GZH91_RS05660 1060791..1061054 + 264 WP_198415461.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GZH91_RS05665 1061056..1061481 + 426 WP_147073959.1 type II toxin-antitoxin system VapC family toxin Toxin
GZH91_RS05670 1061530..1062477 - 948 WP_147073961.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
GZH91_RS05675 1062497..1062751 - 255 WP_147073963.1 Txe/YoeB family addiction module toxin -
GZH91_RS05680 1062741..1063001 - 261 WP_147073965.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
GZH91_RS05685 1063061..1063516 - 456 WP_147073967.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
GZH91_RS05690 1063513..1063983 - 471 WP_147073970.1 lipoprotein signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-118)

Antitoxin

SpoVT-AbrB domain

(20-62)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14992.19 Da        Isoelectric Point: 4.3430

>T33506 WP_147073959.1 NZ_AP021884:1061056-1061481 [Sulfuriferula plumbiphila]
VSGYRYLLDTNILSSLLKQPAGAVASRINAVGEDAICTSVVVACELRYGAAKKGSQILSDKIEQLLSAIEVLPFETGADE
KYAEVRTALEKLGTPIGANDYMIAAHTLLLGLTLVTDNIGEFTRVPGLGVENWLEPLTGVD

Download         Length: 426 bp

>T33506 NZ_AP021884:1061056-1061481 [Sulfuriferula plumbiphila]
GTGTCAGGCTATCGCTATCTGCTTGATACCAACATCCTGAGTAGCCTGCTCAAGCAACCGGCTGGGGCAGTAGCCAGCCG
AATCAATGCAGTCGGTGAAGACGCAATTTGCACCAGTGTCGTGGTCGCCTGTGAATTGCGCTATGGTGCGGCAAAGAAAG
GGTCTCAAATTTTGTCGGACAAGATTGAGCAATTGCTGTCCGCGATTGAGGTGCTGCCGTTCGAAACTGGGGCTGACGAG
AAATATGCCGAGGTACGCACAGCGCTGGAGAAACTTGGTACGCCAATTGGCGCGAACGACTATATGATCGCAGCCCACAC
GCTGTTGCTAGGGCTCACATTGGTGACGGACAACATAGGTGAATTTACCCGGGTTCCCGGCCTCGGGGTCGAGAATTGGC
TGGAACCGTTGACCGGCGTTGATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9935.52 Da        Isoelectric Point: 5.1896

>AT33506 WP_198415461.1 NZ_AP021884:1060791-1061054 [Sulfuriferula plumbiphila]
MPSCANKEATMLTERHVRLFKNGRNQAIRIPREFELSGTEAIIRKEGNRLIIEPLPRRSLLGLLAGWEPMEENFPVVEDL
PAEPVEL

Download         Length: 264 bp

>AT33506 NZ_AP021884:1060791-1061054 [Sulfuriferula plumbiphila]
ATGCCAAGCTGCGCCAACAAGGAGGCCACCATGTTAACCGAGCGCCATGTACGTCTATTCAAGAACGGTCGTAACCAGGC
GATACGCATTCCCCGCGAGTTCGAACTGTCGGGTACTGAAGCCATCATCCGCAAAGAAGGTAATCGCTTGATTATTGAAC
CGCTGCCGCGTCGTTCGTTACTGGGATTGCTCGCCGGATGGGAGCCGATGGAAGAGAATTTCCCCGTGGTCGAGGATTTG
CCTGCCGAACCGGTGGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References