Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/AbrB(antitoxin)
Location 515982..516561 Replicon chromosome
Accession NZ_AP021884
Organism Sulfuriferula plumbiphila strain Gro7

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GZH91_RS02720 Protein ID WP_147074382.1
Coordinates 516196..516561 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GZH91_RS02715 Protein ID WP_147074380.1
Coordinates 515982..516206 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH91_RS02685 511262..511510 + 249 WP_147074368.1 hypothetical protein -
GZH91_RS02690 511673..511963 + 291 WP_147074370.1 hypothetical protein -
GZH91_RS02695 512060..513316 + 1257 WP_147074372.1 porin -
GZH91_RS02700 513613..514914 + 1302 WP_147074374.1 OprD family outer membrane porin -
GZH91_RS02705 515065..515310 + 246 WP_147074376.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GZH91_RS02710 515307..515696 + 390 WP_147074378.1 type II toxin-antitoxin system VapC family toxin -
GZH91_RS02715 515982..516206 + 225 WP_147074380.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GZH91_RS02720 516196..516561 + 366 WP_147074382.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GZH91_RS02725 516915..517541 + 627 WP_198415450.1 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone monooxygenase -
GZH91_RS02730 517571..517888 + 318 WP_147074386.1 DUF2322 family protein -
GZH91_RS02735 517914..518330 - 417 WP_147074388.1 OsmC family protein -
GZH91_RS02740 518361..519107 - 747 WP_147074390.1 YdcF family protein -
GZH91_RS02745 519223..519657 + 435 WP_147074392.1 50S ribosomal protein L13 -
GZH91_RS02750 519661..520053 + 393 WP_124704662.1 30S ribosomal protein S9 -
GZH91_RS02755 520152..521180 + 1029 WP_147074407.1 N-acetyl-gamma-glutamyl-phosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin

SpoVT-AbrB domain

(5-42)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13115.21 Da        Isoelectric Point: 11.4676

>T33505 WP_147074382.1 NZ_AP021884:516196-516561 [Sulfuriferula plumbiphila]
VSYERFDVVKVPFPFTDRDQTKRRPALVVSGNAGFNARAGHSVMAMITSAKHAAWPLDVPVTDLAAAALPAPSVVRMKLF
TLDHRLVLGKIGRLTGSDEAAVTRALEKLCGRTTTSARSRR

Download         Length: 366 bp

>T33505 NZ_AP021884:516196-516561 [Sulfuriferula plumbiphila]
GTGAGCTATGAACGCTTCGATGTGGTGAAGGTGCCTTTCCCTTTCACCGACAGGGATCAAACCAAAAGGCGCCCGGCGCT
GGTCGTGTCCGGCAACGCTGGATTCAATGCACGAGCCGGGCATAGTGTGATGGCGATGATTACCAGCGCGAAGCATGCCG
CATGGCCCTTGGATGTGCCTGTCACGGATTTGGCGGCGGCGGCTCTGCCCGCGCCGTCCGTGGTGCGGATGAAATTGTTT
ACCCTGGATCACCGCCTGGTGCTGGGTAAAATAGGTCGCCTGACCGGGTCTGATGAAGCGGCCGTGACCCGGGCGCTGGA
AAAATTATGCGGGCGAACAACCACGTCGGCGAGGTCGCGGCGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8211.25 Da        Isoelectric Point: 5.0190

>AT33505 WP_147074380.1 NZ_AP021884:515982-516206 [Sulfuriferula plumbiphila]
MLTSKVTSKYQATIPAEVRKKLGIHSGDTLAFEVVNDEVRLRRATPLDLQYAQALAATLGEWDSASDTEAYREL

Download         Length: 225 bp

>AT33505 NZ_AP021884:515982-516206 [Sulfuriferula plumbiphila]
ATGCTGACGAGCAAGGTGACAAGCAAGTACCAGGCGACCATTCCGGCGGAGGTGCGCAAAAAACTGGGCATACACAGCGG
CGATACGCTGGCGTTCGAGGTGGTCAACGACGAGGTCAGGTTGCGCCGCGCGACGCCGCTCGATCTCCAGTATGCACAGG
CTTTGGCCGCAACCCTGGGGGAGTGGGATTCGGCCAGTGACACCGAAGCTTACCGTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References