Detailed information of TA system TA033502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 332085..332620
• Replicon: chromosome
• Accession: NZ_AP021884
• Organism: Sulfuriferula plumbiphila strain Gro7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GZH91_RS01705
• Protein ID: WP_147072061.1
• Coordinates: 332345..332620 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GZH91_RS01700
• Protein ID: WP_147072062.1
• Coordinates: 332085..332345 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZH91_RS01665	328065..328877	+	813	WP_147072076.1	integrase domain-containing protein	-
GZH91_RS01670	329270..329539	-	270	WP_147072074.1	hypothetical protein	-
GZH91_RS01675	329644..330147	+	504	WP_147072072.1	hypothetical protein	-
GZH91_RS01680	330396..330665	+	270	WP_147072070.1	DUF4258 domain-containing protein	-
GZH91_RS01685	330662..330865	+	204	WP_147072068.1	DUF2283 domain-containing protein	-
GZH91_RS01690	331194..331490	+	297	WP_147072066.1	DUF1778 domain-containing protein	-
GZH91_RS01695	331459..332019	+	561	WP_147072064.1	hypothetical protein	-
GZH91_RS01700	332085..332345	+	261	WP_147072062.1	ribbon-helix-helix domain-containing protein	Antitoxin
GZH91_RS01705	332345..332620	+	276	WP_147072061.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GZH91_RS01710	332903..333307	-	405	WP_147072060.1	DUF2384 domain-containing protein	-
GZH91_RS01715	333410..334234	-	825	WP_147072059.1	PRTRC system ThiF family protein	-
GZH91_RS01720	334222..334914	-	693	WP_198415447.1	PRTRC system protein A	-
GZH91_RS01725	334910..335395	-	486	WP_198415515.1	PRTRC system protein B	-
GZH91_RS01730	335304..336227	-	924	WP_198415360.1	autoinducer binding domain-containing protein	-
GZH91_RS01735	336437..336823	+	387	WP_198415448.1	DUF4902 domain-containing protein	-
GZH91_RS01740	336907..337497	+	591	WP_147072053.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	325086..350844	25758

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10667.23 Da
• Isoelectric Point: 7.2025

>T33502 WP_147072061.1 NZ_AP021884:332345-332620 [Sulfuriferula plumbiphila]
MELKWTSKGLSDLARLYEFLAPVNGQAAARTVQSLTAAPVSLLANPRIGEKLEEFEPREVRRIMVGHYEMRYEIQESTLY
VLRFWHTREDR

Nucleotide

• Length: 276 bp

>T33502 NZ_AP021884:332345-332620 [Sulfuriferula plumbiphila]
ATGGAACTGAAATGGACGAGCAAAGGGCTATCCGATCTCGCGCGGCTTTATGAGTTCCTGGCTCCGGTGAACGGGCAGGC
CGCCGCGCGCACGGTGCAATCCCTGACCGCCGCGCCGGTCAGCCTACTGGCGAATCCACGCATCGGAGAGAAGTTGGAGG
AGTTCGAGCCCCGCGAGGTGCGGCGCATTATGGTCGGGCACTATGAAATGCGCTACGAGATTCAGGAATCCACGCTTTAC
GTGCTGCGGTTCTGGCACACGCGGGAAGACCGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9616.95 Da
• Isoelectric Point: 6.2191

>AT33502 WP_147072062.1 NZ_AP021884:332085-332345 [Sulfuriferula plumbiphila]
MNTKVLTAHVPLPLAEKVDQMAARLERSRGWIVKQALAAWIDQEEERSRLTREALADVDAGHVIDHQAVQAWADSLGTDR
PLPVPR

Nucleotide

• Length: 261 bp

>AT33502 NZ_AP021884:332085-332345 [Sulfuriferula plumbiphila]
ATGAACACCAAAGTACTTACCGCCCATGTCCCACTACCGCTTGCCGAAAAGGTTGATCAGATGGCCGCTCGCTTGGAGCG
CTCGCGTGGCTGGATTGTGAAGCAAGCATTGGCAGCCTGGATCGACCAGGAAGAAGAACGCAGCCGTTTGACACGGGAGG
CACTAGCAGATGTTGATGCCGGGCACGTCATCGACCACCAAGCTGTGCAAGCGTGGGCTGATAGCCTCGGTACCGACAGG
CCGCTGCCGGTGCCGCGCTGA