Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 22933..23516 Replicon plasmid SGTM_pl1
Accession NZ_AP021882
Organism Sulfuriferula nivalis strain SGTM

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SFSGTM_RS16700 Protein ID WP_162086416.1
Coordinates 22933..23313 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SFSGTM_RS16705 Protein ID WP_162086437.1
Coordinates 23310..23516 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFSGTM_RS16670 18087..19184 - 1098 WP_162086410.1 iron-containing redox enzyme family protein -
SFSGTM_RS16675 19575..19913 + 339 WP_162086411.1 hypothetical protein -
SFSGTM_RS16680 20043..20600 - 558 WP_194367992.1 recombinase family protein -
SFSGTM_RS16685 20780..21433 + 654 WP_162086413.1 class I SAM-dependent methyltransferase -
SFSGTM_RS16690 21575..21946 + 372 WP_162086414.1 cupin domain-containing protein -
SFSGTM_RS16695 22538..22774 - 237 WP_162086415.1 hypothetical protein -
SFSGTM_RS16700 22933..23313 - 381 WP_162086416.1 PIN domain-containing protein Toxin
SFSGTM_RS16705 23310..23516 - 207 WP_162086437.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SFSGTM_RS16710 23590..24297 - 708 WP_162086417.1 hypothetical protein -
SFSGTM_RS16715 24299..25066 - 768 WP_162086418.1 hypothetical protein -
SFSGTM_RS16720 25833..26060 + 228 WP_162086419.1 ParD-like family protein -
SFSGTM_RS16725 26057..26335 + 279 WP_162086420.1 type II toxin-antitoxin system RelE/ParE family toxin -
SFSGTM_RS16730 26403..26675 - 273 WP_162086421.1 HU family DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45416 45416
- flank IS/Tn - - 20043..20600 557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14062.41 Da        Isoelectric Point: 4.7822

>T33498 WP_162086416.1 NZ_AP021882:c23313-22933 [Sulfuriferula nivalis]
MNVLIDTSVWIDHFRNGNDVLVNIIELDRAFTHPMVILELACGTPPAPRIKTLNNISFLQSCNQVSLGEVMQFIEHEKLY
GLGCGLVDITLLASTLITPSTELWTLDKRLADLAVRFGVAFEPMLH

Download         Length: 381 bp

>T33498 NZ_AP021882:c23313-22933 [Sulfuriferula nivalis]
ATGAATGTACTCATTGATACCTCGGTGTGGATAGATCACTTCCGAAACGGTAATGATGTATTGGTTAATATCATAGAGCT
AGACCGTGCATTCACTCATCCAATGGTCATACTCGAACTTGCTTGTGGAACACCACCAGCACCCCGCATCAAAACGTTAA
ATAACATTAGCTTTTTGCAATCCTGTAACCAGGTAAGTCTAGGTGAAGTCATGCAATTCATCGAACATGAGAAACTGTAT
GGCCTTGGATGCGGATTAGTAGATATTACATTACTGGCATCTACGCTTATTACACCCAGTACTGAATTATGGACGCTTGA
TAAGCGACTTGCGGATTTAGCTGTACGCTTCGGTGTCGCTTTTGAGCCGATGCTGCATTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7691.80 Da        Isoelectric Point: 5.7809

>AT33498 WP_162086437.1 NZ_AP021882:c23516-23310 [Sulfuriferula nivalis]
MRTTVTIDDALYEQALEMADTNMDKADIFREAIKTFVRVQAAKRLVALGGTMPEIQDIPRRRDHAASQ

Download         Length: 207 bp

>AT33498 NZ_AP021882:c23516-23310 [Sulfuriferula nivalis]
ATGCGCACGACGGTTACTATTGATGATGCCCTCTATGAACAAGCCCTGGAAATGGCCGATACGAACATGGATAAAGCGGA
TATTTTCAGAGAAGCGATTAAAACTTTTGTACGTGTACAAGCCGCCAAGCGGCTTGTCGCACTAGGCGGCACCATGCCTG
AAATTCAAGATATACCGCGCCGCCGTGATCACGCCGCTTCGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References