Detailed information of TA system TA033492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapXD/-
• Location: 1695751..1696232
• Replicon: chromosome
• Accession: NZ_AP021881
• Organism: Sulfuriferula nivalis strain SGTM

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: -
• Locus tag: SFSGTM_RS08370
• Protein ID: WP_162084759.1
• Coordinates: 1695751..1696032 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: VapX
• Uniprot ID: -
• Locus tag: SFSGTM_RS08375
• Protein ID: WP_162084760.1
• Coordinates: 1696032..1696232 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFSGTM_RS08350	1690915..1692021	-	1107	WP_162086256.1	ABC transporter permease	-
SFSGTM_RS08355	1692033..1693820	-	1788	WP_162084757.1	ATP-binding cassette domain-containing protein	-
SFSGTM_RS17050	1693826..1694161	-	336	WP_198420529.1	HlyD family efflux transporter periplasmic adaptor subunit	-
SFSGTM_RS08360	1694134..1694868	-	735	WP_198420530.1	biotin/lipoyl-binding protein	-
SFSGTM_RS08365	1695149..1695706	-	558	WP_162084758.1	recombinase family protein	-
SFSGTM_RS08370	1695751..1696032	-	282	WP_162084759.1	virulence factor	Toxin
SFSGTM_RS08375	1696032..1696232	-	201	WP_162084760.1	DUF5397 domain-containing protein	Antitoxin
SFSGTM_RS08380	1696391..1699369	+	2979	WP_162084761.1	Tn3 family transposase	-
SFSGTM_RS08385	1699423..1700475	+	1053	WP_162084762.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1695149..1699369	4220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

• Protein of unknown function DUF5397 (6-66)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10556.00 Da
• Isoelectric Point: 6.4608

>T33492 WP_162084759.1 NZ_AP021881:c1696032-1695751 [Sulfuriferula nivalis]
MYAVSFDLTVADAEMNHPKGVSQAYTEIGAILGEHGFRRVQGSLYVTDNEDMANLFLAFQTLRARPWFPKSVRDIRAFRI
EQWSDFTAVVKGV

Nucleotide

• Length: 282 bp

>T33492 NZ_AP021881:c1696032-1695751 [Sulfuriferula nivalis]
ATGTACGCAGTTTCCTTTGATCTGACGGTGGCCGACGCCGAGATGAACCACCCAAAAGGGGTTTCACAGGCATACACCGA
GATCGGTGCCATCTTGGGTGAACATGGTTTTCGCCGAGTTCAAGGTAGCTTGTATGTGACAGACAACGAGGACATGGCCA
ATCTCTTCCTTGCCTTCCAAACGTTGCGTGCTCGTCCTTGGTTTCCGAAGTCCGTACGAGATATCCGAGCCTTCCGCATT
GAGCAATGGTCAGATTTTACCGCCGTGGTTAAAGGAGTCTGA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7355.34 Da
• Isoelectric Point: 4.6855

>AT33492 WP_162084760.1 NZ_AP021881:c1696232-1696032 [Sulfuriferula nivalis]
MQAVTTAPPIPTGKIKSFGAFGPKYEVGKPLRQLDDGDWMVEVKMVETGESAEYRLTHVYDDPEAR

Nucleotide

• Length: 201 bp

>AT33492 NZ_AP021881:c1696232-1696032 [Sulfuriferula nivalis]
ATGCAAGCCGTGACGACTGCCCCGCCCATACCCACGGGCAAGATCAAGAGCTTTGGTGCGTTCGGGCCAAAGTACGAAGT
TGGCAAGCCACTTCGCCAGTTGGATGATGGTGACTGGATGGTCGAGGTCAAGATGGTCGAGACAGGCGAGTCCGCCGAAT
ATCGGTTGACACATGTTTACGATGATCCAGAGGCTCGCTAA