Detailed information of TA system TA033491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1530792..1531327
• Replicon: chromosome
• Accession: NZ_AP021881
• Organism: Sulfuriferula nivalis strain SGTM

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SFSGTM_RS07780
• Protein ID: WP_162086246.1
• Coordinates: 1530792..1531112 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: SFSGTM_RS07785
• Protein ID: WP_162084665.1
• Coordinates: 1531112..1531327 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFSGTM_RS07770	1526284..1528431	+	2148	WP_162084663.1	peptidase M50	-
SFSGTM_RS07775	1528424..1530415	+	1992	WP_162084664.1	preprotein translocase subunit SecA	-
SFSGTM_RS07780	1530792..1531112	-	321	WP_162086246.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SFSGTM_RS07785	1531112..1531327	-	216	WP_162084665.1	antitoxin MazE family protein	Antitoxin
SFSGTM_RS07790	1531723..1531882	-	160	Protein_1530	IS630 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-104)

Antitoxin

• Antitoxin MazE-like (7-70)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11586.61 Da
• Isoelectric Point: 7.9848

>T33491 WP_162086246.1 NZ_AP021881:c1531112-1530792 [Sulfuriferula nivalis]
IQRGDLVTVSLQGDYGKPRPALIIQSNLLTELESVVLCPVTSDLRNAAFRVTVEPNPANGLRVLSQVMVDKLSTLPRAKI
SEPIGRLDDERMKAIDRVLLLVVGVI

Nucleotide

• Length: 321 bp

>T33491 NZ_AP021881:c1531112-1530792 [Sulfuriferula nivalis]
ATACAGCGAGGCGACCTCGTGACAGTTTCATTGCAAGGTGACTACGGTAAACCACGGCCAGCATTGATCATTCAATCAAA
CCTGCTAACCGAACTGGAAAGCGTCGTGCTGTGTCCAGTGACAAGCGATCTGCGCAATGCCGCGTTTCGTGTCACTGTAG
AACCGAATCCAGCTAACGGGCTGCGCGTGCTATCGCAAGTCATGGTGGACAAGCTCTCGACGCTGCCGCGTGCCAAAATC
AGCGAGCCGATTGGCCGCCTTGATGATGAGCGGATGAAAGCGATAGATAGAGTGCTCCTGTTGGTCGTCGGCGTTATTTG
A

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8134.15 Da
• Isoelectric Point: 6.7172

>AT33491 WP_162084665.1 NZ_AP021881:c1531327-1531112 [Sulfuriferula nivalis]
MPSIHESKVARHRERMRAAGLRPVQFWVPDTRSPEFTAQVRMQCQSLKGDPAEAEALRFTEEAASHVEGWE

Nucleotide

• Length: 216 bp

>AT33491 NZ_AP021881:c1531327-1531112 [Sulfuriferula nivalis]
ATGCCATCAATTCACGAATCAAAAGTAGCGCGGCACCGAGAGCGAATGCGCGCGGCGGGGCTACGGCCTGTCCAGTTTTG
GGTGCCAGACACTCGCTCGCCTGAGTTCACGGCGCAAGTGCGCATGCAGTGCCAAAGCCTGAAGGGCGATCCAGCAGAAG
CTGAGGCTTTGCGCTTCACCGAAGAGGCAGCATCGCACGTTGAGGGTTGGGAGTGA