Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1508293..1508840 Replicon chromosome
Accession NZ_AP021881
Organism Sulfuriferula nivalis strain SGTM

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SFSGTM_RS07690 Protein ID WP_174237403.1
Coordinates 1508293..1508619 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SFSGTM_RS07695 Protein ID WP_162084650.1
Coordinates 1508616..1508840 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFSGTM_RS07670 1503984..1505426 + 1443 WP_162084646.1 sulfate adenylyltransferase subunit CysD -
SFSGTM_RS07675 1505426..1506574 + 1149 Protein_1507 50S ribosome-binding GTPase -
SFSGTM_RS07680 1506625..1507388 + 764 WP_162084647.1 IS5 family transposase -
SFSGTM_RS07685 1507428..1508159 + 732 WP_162084648.1 adenylyl-sulfate kinase -
SFSGTM_RS07690 1508293..1508619 - 327 WP_174237403.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SFSGTM_RS07695 1508616..1508840 - 225 WP_162084650.1 antitoxin MazE family protein Antitoxin
SFSGTM_RS07700 1509671..1509931 - 261 WP_162084651.1 helix-turn-helix domain-containing protein -
SFSGTM_RS07705 1510083..1510313 + 231 WP_162084652.1 hypothetical protein -
SFSGTM_RS07710 1510328..1511617 + 1290 WP_198420629.1 site-specific integrase -
SFSGTM_RS07715 1511610..1511930 + 321 WP_162084653.1 hypothetical protein -
SFSGTM_RS07720 1511930..1512649 + 720 WP_162084654.1 TraI domain-containing protein -
SFSGTM_RS07725 1512796..1513044 + 249 WP_162084655.1 hypothetical protein -
SFSGTM_RS07730 1513147..1513485 + 339 WP_179954407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1507035..1507388 353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(8-72)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11798.97 Da        Isoelectric Point: 9.2182

>T33490 WP_174237403.1 NZ_AP021881:c1508619-1508293 [Sulfuriferula nivalis]
VMRGDFVTIAMQGDFGKPRPALVIQADMFNELATITLLPVTSTLVGAPLFRVTVQPNEKNGLQKPSQVMVDKAITVKREK
VGNTLGHIDTVTMIEIERCMAVFIGISK

Download         Length: 327 bp

>T33490 NZ_AP021881:c1508619-1508293 [Sulfuriferula nivalis]
GTGATGCGAGGTGATTTCGTGACTATCGCTATGCAAGGTGACTTTGGTAAACCAAGACCGGCCTTGGTGATTCAGGCAGA
TATGTTTAACGAGCTTGCGACCATAACACTGCTGCCAGTAACGAGCACGCTGGTTGGCGCCCCGCTATTCCGTGTTACTG
TTCAACCCAATGAAAAAAACGGCCTGCAGAAGCCTTCACAGGTAATGGTAGATAAGGCAATTACTGTAAAACGTGAAAAG
GTTGGGAATACCCTAGGACATATTGATACAGTTACGATGATAGAAATTGAGCGTTGCATGGCCGTGTTTATAGGAATATC
CAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8524.52 Da        Isoelectric Point: 5.5794

>AT33490 WP_162084650.1 NZ_AP021881:c1508840-1508616 [Sulfuriferula nivalis]
MANTHVNTRVQKHRDMLRMAGLRPVQIWVPDTRRSDFAEECHRQSRLAAESDVANKDIGQFMDEALADVDGWTE

Download         Length: 225 bp

>AT33490 NZ_AP021881:c1508840-1508616 [Sulfuriferula nivalis]
ATGGCAAACACACACGTAAATACCCGGGTTCAAAAACATCGCGACATGCTACGCATGGCTGGACTTCGTCCTGTGCAAAT
TTGGGTACCAGATACACGACGTTCAGACTTTGCGGAGGAATGTCACCGCCAGAGCCGCCTTGCTGCCGAATCCGATGTAG
CCAACAAAGATATAGGGCAGTTCATGGACGAAGCTTTGGCTGACGTTGATGGTTGGACGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References