Detailed information of TA system TA033489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1076061..1076824
• Replicon: chromosome
• Accession: NZ_AP021881
• Organism: Sulfuriferula nivalis strain SGTM

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: SFSGTM_RS05630
• Protein ID: WP_162084333.1
• Coordinates: 1076330..1076824 (+)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: SFSGTM_RS05625
• Protein ID: WP_162084332.1
• Coordinates: 1076061..1076333 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SFSGTM_RS05590	1071187..1071636	+	450	WP_162084326.1	hypothetical protein	-
SFSGTM_RS05595	1071648..1072151	+	504	WP_162084327.1	glycine zipper 2TM domain-containing protein	-
SFSGTM_RS05600	1072847..1073224	+	378	WP_162084328.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SFSGTM_RS05605	1073256..1073537	+	282	WP_198420650.1	helix-turn-helix domain-containing protein	-
SFSGTM_RS05610	1073779..1074072	-	294	WP_162084330.1	BrnA antitoxin family protein	-
SFSGTM_RS05615	1074050..1074325	-	276	WP_162086216.1	BrnT family toxin	-
SFSGTM_RS05620	1074486..1075496	-	1011	WP_162084331.1	site-specific integrase	-
SFSGTM_RS05625	1076061..1076333	+	273	WP_162084332.1	DUF1778 domain-containing protein	Antitoxin
SFSGTM_RS05630	1076330..1076824	+	495	WP_162084333.1	GNAT family N-acetyltransferase	Toxin
SFSGTM_RS05635	1077109..1078104	+	996	WP_162084334.1	ABC transporter substrate-binding protein	-
SFSGTM_RS05640	1078139..1079104	+	966	WP_162084335.1	ABC transporter permease	-
SFSGTM_RS05645	1079128..1080039	+	912	WP_162086217.1	ABC transporter ATP-binding protein	-
SFSGTM_RS05650	1080120..1081481	+	1362	WP_162084336.1	type III glutamate--ammonia ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (26-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-80)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17886.67 Da
• Isoelectric Point: 9.8740

>T33489 WP_162084333.1 NZ_AP021881:1076330-1076824 [Sulfuriferula nivalis]
VSLQLNAPQPLAATHILDGFECGEAVLDEWLKRRAMTNQLSGASRTFVVADQNGRVFGYYAMAAGAVAHQMATSSVRRNM
PDPVPVMVLARLAVDHQAQGIKLGASLLQDAVNRAVVVAQNAGVRALLVHALHDRAKEFYEKYGFQWSPLHPLTLMLRLS
TSKP

Nucleotide

• Length: 495 bp

>T33489 NZ_AP021881:1076330-1076824 [Sulfuriferula nivalis]
GTGAGCTTGCAACTCAATGCTCCTCAACCGCTAGCGGCTACCCACATTTTGGATGGGTTTGAGTGCGGTGAGGCCGTTCT
TGATGAATGGCTCAAGCGCCGCGCAATGACCAACCAATTGAGCGGAGCCAGTCGCACGTTTGTAGTGGCGGATCAGAACG
GCCGTGTTTTTGGCTACTACGCCATGGCTGCGGGCGCAGTCGCGCACCAGATGGCAACGAGCTCGGTGCGTAGAAACATG
CCCGATCCAGTTCCGGTGATGGTGCTGGCCCGATTGGCAGTTGATCATCAAGCGCAGGGCATCAAGCTTGGCGCATCCCT
ACTCCAAGACGCCGTCAACCGGGCTGTTGTGGTTGCGCAGAACGCGGGTGTTCGAGCGTTGCTGGTGCATGCGCTTCATG
ACCGCGCCAAGGAATTCTACGAAAAATATGGTTTTCAGTGGTCGCCATTGCATCCATTGACGCTGATGCTGAGATTGAGT
ACCAGCAAGCCATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10049.56 Da
• Isoelectric Point: 6.4557

>AT33489 WP_162084332.1 NZ_AP021881:1076061-1076333 [Sulfuriferula nivalis]
MRDAAINLRALPEQRDLIDHAATLLGKNRSDFMLEAACDKAQAVVLDQVFFRLNADKFQQFTAMLDAPPSHNPGLERLMA
VAAPWNKAKE

Nucleotide

• Length: 273 bp

>AT33489 NZ_AP021881:1076061-1076333 [Sulfuriferula nivalis]
ATGCGCGACGCCGCTATTAATTTACGGGCATTGCCCGAGCAGCGAGACTTGATTGATCATGCTGCAACGCTGTTAGGTAA
GAATCGCTCGGATTTCATGCTCGAGGCTGCCTGCGACAAAGCACAGGCGGTAGTGCTTGATCAGGTTTTTTTTCGCCTGA
ATGCCGACAAGTTCCAGCAGTTCACGGCAATGCTTGATGCCCCGCCTAGTCATAATCCAGGGCTTGAACGCCTCATGGCG
GTAGCTGCTCCCTGGAACAAAGCCAAGGAGTGA