Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 386271..387316 Replicon chromosome
Accession NZ_AP021881
Organism Sulfuriferula nivalis strain SGTM

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag SFSGTM_RS02020 Protein ID WP_162083699.1
Coordinates 386271..386849 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag SFSGTM_RS02025 Protein ID WP_162083700.1
Coordinates 386849..387316 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFSGTM_RS01985 381910..382386 + 477 WP_162083692.1 hypothetical protein -
SFSGTM_RS01990 382386..384086 + 1701 WP_162083693.1 AAA family ATPase -
SFSGTM_RS01995 384083..384358 + 276 WP_162083694.1 hypothetical protein -
SFSGTM_RS02000 384396..385079 + 684 WP_162083695.1 fumarylacetoacetate hydrolase family protein -
SFSGTM_RS16980 385094..385258 + 165 WP_174237384.1 hypothetical protein -
SFSGTM_RS02005 385281..385529 + 249 WP_162083696.1 BolA/IbaG family iron-sulfur metabolism protein -
SFSGTM_RS02010 385545..385862 + 318 WP_162083697.1 Grx4 family monothiol glutaredoxin -
SFSGTM_RS02015 385881..386240 + 360 WP_162083698.1 hypothetical protein -
SFSGTM_RS02020 386271..386849 - 579 WP_162083699.1 PIN domain-containing protein Toxin
SFSGTM_RS02025 386849..387316 - 468 WP_162083700.1 helix-turn-helix domain-containing protein Antitoxin
SFSGTM_RS02030 387541..387813 + 273 WP_162083701.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SFSGTM_RS02035 387810..388139 + 330 WP_162083702.1 type II toxin-antitoxin system RelE/ParE family toxin -
SFSGTM_RS02040 388260..388565 + 306 WP_162083703.1 IS66 family insertion sequence element accessory protein TnpB -
SFSGTM_RS02045 388562..388921 + 360 WP_162083704.1 IS66 family insertion sequence element accessory protein TnpB -
SFSGTM_RS02050 389002..390585 + 1584 WP_162083705.1 IS66 family transposase -
SFSGTM_RS02055 390651..391738 + 1088 WP_162083368.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 382386..406958 24572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-116)

Antitoxin

SinI-like, DNA-binding domain

(84-129)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21253.29 Da        Isoelectric Point: 4.8555

>T33487 WP_162083699.1 NZ_AP021881:c386849-386271 [Sulfuriferula nivalis]
MSGSARYTAILDACVLYPAPLRDLLLSLARSGLYHARWTSDIQNEWVRNLLANRPDLKSDDIERTCRAMNSSVLDCMVEN
YETIASTLTLPDPGDTHVLGATIIGHADAIVTFNLKDFPAEVLSPFNIEAQHPDDFIANQLELREIEALAAIKAMRARLR
NPPKTANELIATFERNQLPLTASILRAAADLI

Download         Length: 579 bp

>T33487 NZ_AP021881:c386849-386271 [Sulfuriferula nivalis]
ATGTCCGGGTCGGCACGTTACACTGCCATTCTCGATGCATGTGTATTGTATCCAGCGCCATTGCGCGATTTGCTATTAAG
CCTTGCCCGGTCTGGGCTATATCATGCGCGCTGGACAAGTGACATACAAAACGAATGGGTCAGAAATTTACTAGCCAATC
GCCCGGATTTAAAGTCCGATGATATTGAGCGCACCTGCCGGGCAATGAATAGCAGCGTACTGGATTGCATGGTCGAGAAT
TACGAAACTATTGCGAGCACGCTAACATTACCCGATCCGGGAGATACCCATGTATTGGGTGCCACAATCATCGGACACGC
GGATGCAATCGTCACGTTTAATCTTAAAGATTTCCCGGCGGAAGTGTTGAGCCCATTTAATATAGAAGCCCAGCATCCAG
ATGACTTTATTGCCAATCAACTGGAACTGCGTGAAATTGAGGCTCTGGCAGCGATCAAAGCCATGCGTGCCCGGCTACGC
AATCCACCAAAAACTGCAAATGAGCTGATTGCCACTTTTGAGCGCAATCAATTACCCTTAACAGCATCGATACTACGCGC
TGCAGCTGACTTGATTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17405.94 Da        Isoelectric Point: 6.0928

>AT33487 WP_162083700.1 NZ_AP021881:c387316-386849 [Sulfuriferula nivalis]
MSTSTLNESALNEHDAELAKIAQRCIMAALDHSRAHKIILVDDNDQSGNPPTLEVPPQALRLFAEILGKMAQRQPFSLIP
QKLLLSTQEAANILNVSRPFVVKQLEANKIEYIRVGRHRRIAFDKLIEYQNSMLREADDALQTLADQAQALDMGY

Download         Length: 468 bp

>AT33487 NZ_AP021881:c387316-386849 [Sulfuriferula nivalis]
ATGTCCACATCTACACTAAATGAATCAGCACTCAATGAGCACGACGCCGAACTCGCCAAGATTGCCCAGCGTTGCATCAT
GGCCGCTCTGGATCATTCACGTGCGCACAAAATCATTCTGGTTGATGATAACGATCAAAGCGGCAATCCGCCTACGCTTG
AAGTGCCACCACAAGCACTTCGCCTGTTCGCGGAAATCCTGGGGAAAATGGCACAACGCCAACCCTTTTCACTGATCCCG
CAAAAACTGTTACTCAGTACGCAAGAGGCAGCAAACATCCTGAATGTCTCGCGCCCCTTCGTGGTCAAACAACTCGAAGC
AAACAAAATCGAATATATCCGCGTTGGCCGTCATCGCCGCATTGCGTTCGACAAGTTAATCGAGTATCAAAATTCAATGC
TGCGCGAAGCAGACGACGCATTGCAAACATTGGCTGACCAGGCGCAAGCTCTGGATATGGGTTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References