Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 217090..217667 Replicon chromosome
Accession NZ_AP021881
Organism Sulfuriferula nivalis strain SGTM

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SFSGTM_RS01170 Protein ID WP_162083556.1
Coordinates 217332..217667 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SFSGTM_RS01165 Protein ID WP_162083555.1
Coordinates 217090..217332 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFSGTM_RS01120 213162..214394 - 1233 WP_162083547.1 transposase -
SFSGTM_RS01125 214415..214831 + 417 WP_162083548.1 IS200/IS605 family transposase -
SFSGTM_RS01130 214806..215060 + 255 WP_198420593.1 BrnT family toxin -
SFSGTM_RS01135 215044..215310 + 267 WP_162083550.1 BrnA antitoxin family protein -
SFSGTM_RS01145 215603..215890 + 288 WP_162083551.1 CopG family transcriptional regulator -
SFSGTM_RS01150 215893..216183 + 291 WP_162083552.1 type II toxin-antitoxin system RelE/ParE family toxin -
SFSGTM_RS01155 216193..216543 - 351 WP_162083553.1 HigA family addiction module antidote protein -
SFSGTM_RS01160 216555..216836 - 282 WP_162083554.1 type II toxin-antitoxin system RelE/ParE family toxin -
SFSGTM_RS01165 217090..217332 + 243 WP_162083555.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SFSGTM_RS01170 217332..217667 + 336 WP_162083556.1 endoribonuclease MazF Toxin
SFSGTM_RS01175 217748..218149 - 402 WP_162086150.1 type II toxin-antitoxin system MqsA family antitoxin -
SFSGTM_RS01180 218152..218325 - 174 WP_198420594.1 type II toxin-antitoxin system MqsR family toxin -
SFSGTM_RS01185 218744..220288 + 1545 WP_162083557.1 plasmid recombination protein -
SFSGTM_RS01190 220356..221315 - 960 WP_162083558.1 acetyltransferase -
SFSGTM_RS01195 221366..222463 - 1098 WP_162083559.1 DUF1972 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 214463..214831 368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-108)

Antitoxin

(1-79)


Sequences


Toxin        


Download         Length: 112 a.a.        Molecular weight: 12048.93 Da        Isoelectric Point: 8.4839

>T33485 WP_162083556.1 NZ_AP021881:217332-217667 [Sulfuriferula nivalis]
MGQSYVPESGDIVWLQFDPQAGHEQAGHRPAVVVSPASYNGKTGLMLCCLITTQIKGYPFEVVIAGDRSSAVLSDQIKSL
DWVARKATYKGKITPDELMIVRNKVSALIGK

Download         Length: 336 bp

>T33485 NZ_AP021881:217332-217667 [Sulfuriferula nivalis]
ATGGGGCAAAGCTATGTACCTGAATCAGGTGATATTGTGTGGTTACAATTCGATCCGCAGGCAGGGCATGAGCAAGCCGG
GCATAGGCCAGCGGTAGTTGTCAGTCCCGCATCCTACAATGGTAAAACCGGATTGATGTTGTGTTGCCTGATAACTACGC
AGATCAAAGGTTATCCATTCGAGGTTGTGATCGCTGGTGATCGATCAAGTGCCGTGTTGTCTGACCAGATAAAAAGTCTC
GATTGGGTTGCGCGCAAGGCTACTTATAAGGGAAAAATAACTCCCGATGAGTTAATGATAGTGCGAAATAAAGTATCTGC
CCTTATTGGCAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8642.95 Da        Isoelectric Point: 4.3466

>AT33485 WP_162083555.1 NZ_AP021881:217090-217332 [Sulfuriferula nivalis]
MRVIVKKWGNSAAVRIPAGIMESACLSLDASVDVREEGGRIIIEPIRSTEYDLAQLLADITPENLNIGADFGTPVGKEFL

Download         Length: 243 bp

>AT33485 NZ_AP021881:217090-217332 [Sulfuriferula nivalis]
ATGCGTGTAATCGTGAAGAAATGGGGAAACAGTGCTGCTGTTCGTATCCCTGCTGGAATAATGGAATCAGCTTGTTTGAG
TCTGGATGCGTCGGTTGATGTTCGGGAAGAAGGTGGCCGTATTATTATCGAGCCGATTCGGTCAACTGAATATGATCTGG
CGCAATTGCTTGCTGACATCACACCAGAAAATTTGAATATCGGCGCTGATTTTGGTACGCCAGTCGGCAAGGAGTTTTTG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References