Detailed information of TA system TA033463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 7292687..7293360
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GN112_RS31970
• Protein ID: WP_155313826.1
• Coordinates: 7292935..7293360 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GN112_RS31965
• Protein ID: WP_155313825.1
• Coordinates: 7292687..7292938 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS31940	7287998..7288456	+	459	WP_155309045.1	hypothetical protein	-
GN112_RS31945	7288740..7289468	+	729	WP_155314165.1	hypothetical protein	-
GN112_RS31950	7289478..7290353	+	876	WP_155313824.1	tyrosine-type recombinase/integrase	-
GN112_RS31955	7290340..7291353	+	1014	WP_155308523.1	site-specific integrase	-
GN112_RS31960	7291543..7292106	+	564	WP_197743412.1	hypothetical protein	-
GN112_RS31965	7292687..7292938	+	252	WP_155313825.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GN112_RS31970	7292935..7293360	+	426	WP_155313826.1	type II toxin-antitoxin system VapC family toxin	Toxin
GN112_RS31975	7294345..7295730	+	1386	WP_155313827.1	hypothetical protein	-
GN112_RS31980	7295935..7297053	+	1119	WP_155310575.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	7279384..7303678	24294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15681.92 Da
• Isoelectric Point: 7.2768

>T33463 WP_155313826.1 NZ_AP021879:7292935-7293360 [Desulfosarcina ovata subsp. ovata]
MNYLLDTCVISELVKATPNGNVINWISHTPNERLFLSVITIGEIRKGITKLPDSKKKHRLTDWLNTLLENYEERIYPVDL
AVAESWGSIQGKAENNGTPVASVDSLIAAVAQTHNLIVVTRNEKDFAATNVTIVNPWKNKG

Nucleotide

• Length: 426 bp

>T33463 NZ_AP021879:7292935-7293360 [Desulfosarcina ovata subsp. ovata]
TTGAATTATTTATTAGACACTTGTGTGATATCAGAATTGGTCAAAGCAACTCCAAATGGAAACGTCATAAATTGGATAAG
CCATACACCGAATGAAAGACTATTCTTATCTGTCATAACCATTGGAGAGATACGAAAAGGTATTACCAAACTTCCGGACT
CAAAAAAGAAACATCGGCTTACAGATTGGCTTAATACATTATTGGAAAATTACGAGGAAAGAATCTACCCTGTTGATTTA
GCTGTTGCAGAGAGTTGGGGAAGTATCCAGGGAAAAGCTGAGAATAACGGTACTCCTGTCGCCTCCGTTGACAGTTTGAT
CGCAGCTGTGGCCCAAACACACAATTTAATTGTCGTAACAAGAAACGAAAAAGATTTTGCTGCAACCAATGTTACAATAG
TGAATCCATGGAAAAATAAAGGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9744.24 Da
• Isoelectric Point: 9.5068

>AT33463 WP_155313825.1 NZ_AP021879:7292687-7292938 [Desulfosarcina ovata subsp. ovata]
MNTSWKLQDAKAKFSQVVENALKMGPQYVTRRGREAVVVLSVKEYQKITTPKPTLKEFLLNCPKMDDGFEFERQKDYPRD
VEF

Nucleotide

• Length: 252 bp

>AT33463 NZ_AP021879:7292687-7292938 [Desulfosarcina ovata subsp. ovata]
ATGAATACATCATGGAAATTACAAGACGCTAAGGCAAAATTCAGTCAGGTTGTCGAAAATGCTTTGAAAATGGGGCCTCA
GTATGTAACGCGTAGAGGCCGGGAAGCCGTAGTTGTCTTATCCGTTAAAGAATATCAAAAAATAACCACCCCTAAACCAA
CACTGAAAGAGTTCCTTTTAAATTGCCCCAAAATGGATGATGGTTTTGAATTTGAAAGACAAAAAGATTATCCGAGGGAT
GTGGAATTTTGA