Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 6829012..6830669 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag GN112_RS29990 Protein ID WP_155314454.1
Coordinates 6829362..6830669 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag GN112_RS29985 Protein ID WP_155313505.1
Coordinates 6829012..6829365 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS29970 6824248..6826116 + 1869 WP_155309028.1 hypothetical protein -
GN112_RS29975 6826179..6826865 + 687 WP_162459177.1 transporter substrate-binding domain-containing protein -
GN112_RS29980 6827300..6828418 - 1119 WP_155309156.1 IS110 family transposase -
GN112_RS29985 6829012..6829365 + 354 WP_155313505.1 helix-turn-helix domain-containing protein Antitoxin
GN112_RS29990 6829362..6830669 + 1308 WP_155314454.1 type II toxin-antitoxin system HipA family toxin Toxin
GN112_RS29995 6831758..6832609 - 852 WP_155313506.1 HD domain-containing protein -
GN112_RS30000 6833115..6833309 + 195 WP_155313507.1 hypothetical protein -
GN112_RS30005 6833537..6834004 + 468 WP_155313508.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48443.97 Da        Isoelectric Point: 7.1507

>T33461 WP_155314454.1 NZ_AP021879:6829362-6830669 [Desulfosarcina ovata subsp. ovata]
MSTYAQVNLWGRTIGAVALQDGQTVAAFEYDPAFAKSGIEIAPLTMPLSTRVYAFPELAYRTFHGLPGLLADSLPDRFGN
ALIDAWLATQGRSAESFNAVERLCYVGQRGTGALEFAPVIGPRNRRSMRLNVDRLVELASQILSQRNHLADSFAGPQKAK
ALANILRVGTSAGGARAKAIIALNPETDEVRSGQVDAGDGFEYWLLKFDGVGGNRDKELEDPRGYGVVEYAYWKMATDAG
ITMSECRLLEENDRRHFMTRRFDRGPRGEKLHMQSLCAMAHLDFNLAGVYAYEQALLVIRQLGLSMDAVEEQFRRMVFNI
VARNQDDHVKNIAFMMTPDGAWSLSPAFDVTYSYNPDGAWTGSHQMTLNGKRDGFTLADFRACARAAMMKRGRAEAIIEA
VQRVVARWRDYADDAGVPPDWRDRIHATLRLERFG

Download         Length: 1308 bp

>T33461 NZ_AP021879:6829362-6830669 [Desulfosarcina ovata subsp. ovata]
ATGAGCACCTATGCGCAAGTGAACCTCTGGGGGCGGACCATTGGTGCGGTCGCCCTGCAGGATGGCCAGACCGTCGCCGC
CTTTGAATACGACCCCGCCTTCGCGAAGAGCGGCATCGAAATCGCTCCCCTGACGATGCCGCTTTCCACCCGGGTGTATG
CGTTTCCGGAACTGGCCTACCGGACTTTTCACGGCCTGCCCGGTCTGCTTGCCGATTCCTTGCCCGACCGTTTCGGCAAC
GCCCTGATCGATGCCTGGCTGGCGACTCAGGGGCGATCGGCGGAATCCTTCAATGCTGTCGAGCGACTCTGTTATGTCGG
GCAACGGGGCACGGGGGCACTTGAATTCGCTCCGGTGATCGGCCCGCGCAACCGGCGTTCCATGCGGCTGAATGTCGACC
GGCTCGTCGAACTGGCGTCGCAAATCCTCAGCCAGCGCAATCATTTGGCCGATTCGTTTGCCGGCCCGCAGAAAGCCAAG
GCCCTGGCGAATATCCTGCGCGTCGGTACGTCTGCGGGCGGTGCCCGGGCCAAGGCGATTATCGCCTTGAACCCGGAAAC
GGATGAGGTCCGTTCGGGGCAGGTCGACGCCGGAGATGGCTTTGAGTACTGGCTGCTCAAATTCGACGGGGTCGGCGGCA
ACCGGGACAAGGAACTGGAGGACCCCAGGGGCTACGGTGTTGTCGAATACGCCTATTGGAAGATGGCCACCGATGCCGGC
ATTACCATGAGCGAGTGCCGCCTGCTTGAGGAGAATGACCGCCGGCATTTCATGACCCGGCGCTTCGATCGCGGCCCCCG
GGGGGAAAAGCTGCACATGCAGTCGCTGTGCGCCATGGCCCATTTGGATTTCAATCTGGCCGGTGTTTATGCCTACGAGC
AGGCCCTGTTGGTCATCCGGCAGCTGGGACTCTCCATGGACGCGGTGGAAGAGCAGTTCCGGCGCATGGTCTTCAACATC
GTCGCCCGCAACCAGGATGACCATGTGAAGAATATCGCTTTTATGATGACACCTGACGGCGCATGGTCACTCTCACCCGC
ATTTGACGTGACCTACAGCTACAACCCCGACGGTGCATGGACCGGCAGCCATCAGATGACACTGAACGGCAAACGGGACG
GTTTCACCCTGGCGGATTTCCGGGCCTGCGCCAGGGCGGCCATGATGAAACGCGGGCGGGCCGAGGCGATCATTGAAGCC
GTGCAGCGCGTCGTTGCCCGTTGGCGCGATTATGCCGACGATGCCGGGGTGCCACCGGACTGGCGGGATCGGATCCACGC
CACCCTACGGTTAGAACGGTTTGGATGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13114.18 Da        Isoelectric Point: 10.5707

>AT33461 WP_155313505.1 NZ_AP021879:6829012-6829365 [Desulfosarcina ovata subsp. ovata]
MTIDKLSKLMTDDAILAELGFRMARCRIDRQLTQAALAHQAGVSKRTVERIEAGASAQMVSVIRICRVLDLVAGIDQWIP
QPDLRPMDLVARKGRTRQRASSSRKTQGADEPWTWDP

Download         Length: 354 bp

>AT33461 NZ_AP021879:6829012-6829365 [Desulfosarcina ovata subsp. ovata]
ATGACGATTGACAAACTTTCAAAACTCATGACCGACGATGCGATTCTGGCCGAGTTGGGCTTTCGCATGGCCCGGTGCCG
TATCGACCGGCAGCTGACCCAGGCGGCGCTGGCCCACCAGGCCGGTGTTTCCAAACGCACCGTGGAGCGCATCGAAGCCG
GCGCATCGGCCCAGATGGTGAGTGTCATCCGTATCTGCAGGGTTTTGGATCTCGTCGCCGGGATCGATCAGTGGATTCCC
CAGCCGGACCTCCGGCCGATGGATCTGGTCGCCCGCAAGGGCCGGACGCGCCAGCGAGCCTCATCTAGCCGCAAGACCCA
GGGCGCGGATGAACCATGGACCTGGGACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References