Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5373223..5373851 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GN112_RS23665 Protein ID WP_155312456.1
Coordinates 5373450..5373851 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GN112_RS23660 Protein ID WP_155312455.1
Coordinates 5373223..5373450 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS23630 5368434..5368694 + 261 WP_155312452.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GN112_RS23635 5368691..5368843 + 153 WP_155312453.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GN112_RS23640 5368923..5370188 + 1266 WP_155308364.1 IS4 family transposase -
GN112_RS23645 5370185..5370343 + 159 WP_155312454.1 type II toxin-antitoxin system YafQ family toxin -
GN112_RS23650 5370848..5371543 + 696 WP_197743458.1 DUF4338 domain-containing protein -
GN112_RS23655 5371599..5373002 + 1404 WP_155308406.1 hypothetical protein -
GN112_RS23660 5373223..5373450 + 228 WP_155312455.1 antitoxin Antitoxin
GN112_RS23665 5373450..5373851 + 402 WP_155312456.1 type II toxin-antitoxin system VapC family toxin Toxin
GN112_RS23670 5374487..5376163 + 1677 WP_155312457.1 IS1634 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5361505..5376163 14658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15165.71 Da        Isoelectric Point: 8.4650

>T33455 WP_155312456.1 NZ_AP021879:5373450-5373851 [Desulfosarcina ovata subsp. ovata]
MKFMLDTNICIYIIKRKPPNVIDRFKRTEISQIGISSITLSELIYGVSRSSKPEQNRLALTQFVAPLEILPYDDEASQYY
GDLRVHLEKQGTPIGALDMLIAAHAISIDCTLVTNNEKEFIRVPKLKIVNWTK

Download         Length: 402 bp

>T33455 NZ_AP021879:5373450-5373851 [Desulfosarcina ovata subsp. ovata]
ATGAAATTCATGCTCGATACAAACATCTGTATTTATATAATCAAAAGAAAGCCTCCCAATGTTATAGACCGTTTCAAACG
AACTGAAATTTCGCAAATAGGTATCTCGTCGATTACCCTGAGTGAACTAATATATGGTGTCTCAAGAAGTTCTAAGCCCG
AACAAAACAGATTGGCTTTAACACAGTTTGTCGCGCCATTAGAAATTTTGCCCTATGACGATGAAGCGTCTCAATATTAT
GGCGATCTAAGAGTCCATTTGGAAAAGCAAGGGACACCTATTGGTGCACTTGATATGCTTATCGCCGCCCATGCGATTTC
AATTGACTGCACTCTGGTCACCAACAACGAAAAAGAATTTATTCGAGTACCGAAATTAAAAATAGTTAACTGGACCAAAT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8752.90 Da        Isoelectric Point: 6.2619

>AT33455 WP_155312455.1 NZ_AP021879:5373223-5373450 [Desulfosarcina ovata subsp. ovata]
MQTAKLFFNGRSQAVRLPKNLRFSGNDVFIRKLGKMVVLIPKDDPWSSLINSIDQFTDDFMDSRNQPDQDSREEF

Download         Length: 228 bp

>AT33455 NZ_AP021879:5373223-5373450 [Desulfosarcina ovata subsp. ovata]
ATGCAAACTGCGAAACTCTTTTTTAATGGTCGAAGCCAAGCGGTAAGGTTACCGAAAAACCTCAGATTTTCTGGCAATGA
TGTTTTTATCAGAAAACTCGGCAAGATGGTTGTCCTTATCCCAAAAGACGACCCTTGGTCATCACTCATCAATAGTATTG
ATCAATTTACAGATGATTTTATGGATAGCAGAAATCAACCTGACCAAGATTCTCGAGAAGAATTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References