Detailed information of TA system TA033451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2831739..2832457
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GN112_RS12640
• Protein ID: WP_197743321.1
• Coordinates: 2831739..2832122 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GN112_RS12645
• Protein ID: WP_173179393.1
• Coordinates: 2832119..2832457 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS12625	2827355..2829205	-	1851	WP_155310548.1	TIGR02556 family CRISPR-associated protein	-
GN112_RS12630	2829202..2829867	-	666	WP_155310549.1	DNA repair protein	-
GN112_RS12635	2830278..2831543	-	1266	WP_155309288.1	IS4 family transposase	-
GN112_RS12640	2831739..2832122	+	384	WP_197743321.1	type II toxin-antitoxin system HicA family toxin	Toxin
GN112_RS12645	2832119..2832457	+	339	WP_173179393.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GN112_RS12650	2832454..2832753	-	300	WP_155310550.1	CRISPR-associated endonuclease Cas2	-
GN112_RS12655	2832756..2833772	-	1017	WP_155310551.1	CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2811314..2850757	39443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14817.29 Da
• Isoelectric Point: 11.5831

>T33451 WP_197743321.1 NZ_AP021879:2831739-2832122 [Desulfosarcina ovata subsp. ovata]
VYERHLFLETVLIYGTIFIVKRKHQKILDAIFIRPVGGNIKWRDIEALFVELGAELSEREGSRIGVRLFGERRVFHRRNY
RPMTVGIVRVRLFGERRVFHRPHPSPNTDKGAVASIRKWLADNGVTP

Nucleotide

• Length: 384 bp

>T33451 NZ_AP021879:2831739-2832122 [Desulfosarcina ovata subsp. ovata]
GTGTATGAAAGGCATTTATTTCTTGAAACGGTACTGATATATGGTACTATCTTTATTGTGAAACGCAAACATCAAAAGAT
CTTGGACGCCATATTTATAAGACCGGTGGGAGGTAATATTAAATGGCGTGATATTGAAGCCTTGTTCGTTGAATTGGGTG
CCGAATTAAGCGAACGTGAAGGTTCACGAATCGGTGTTCGCCTGTTTGGTGAAAGGAGGGTGTTTCACCGACGAAATTAC
CGCCCGATGACCGTCGGCATCGTCCGCGTTCGCCTGTTTGGTGAAAGGAGGGTGTTTCACCGACCGCATCCTTCGCCGAA
TACGGACAAAGGGGCTGTCGCCAGCATTCGAAAATGGTTGGCGGACAACGGAGTAACACCATGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12476.15 Da
• Isoelectric Point: 4.4606

>AT33451 WP_173179393.1 NZ_AP021879:2832119-2832457 [Desulfosarcina ovata subsp. ovata]
MMNIMEINGYQAVIKYDPEIEMFRGEFIGLNGGADFYAGDIDGLRREGETSLKVFLDMCKEDGVDPRKAFSGKFNLRVSP
QLHARIVTRAAAEGKSLNQWVADLLDESISAD

Nucleotide

• Length: 339 bp

>AT33451 NZ_AP021879:2832119-2832457 [Desulfosarcina ovata subsp. ovata]
ATGATGAACATTATGGAAATCAATGGCTATCAGGCGGTCATCAAATATGACCCGGAAATTGAAATGTTTCGTGGAGAATT
CATCGGTCTTAACGGCGGAGCCGATTTTTATGCCGGCGATATTGATGGGCTTCGCAGAGAGGGAGAAACGTCACTAAAGG
TATTCCTGGACATGTGCAAGGAAGACGGGGTGGATCCGCGCAAGGCGTTTTCCGGTAAATTCAACTTGCGTGTATCTCCA
CAGTTGCACGCTCGTATCGTTACCCGCGCCGCCGCAGAGGGGAAAAGCCTGAATCAGTGGGTAGCGGACCTGCTCGATGA
GTCCATCAGCGCCGATTAA