Detailed information of TA system TA033450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1919024..1919652
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GN112_RS08730
• Protein ID: WP_155309851.1
• Coordinates: 1919024..1919425 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GN112_RS08735
• Protein ID: WP_155309852.1
• Coordinates: 1919422..1919652 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS08700	1914523..1914825	-	303	WP_155309846.1	hypothetical protein	-
GN112_RS08705	1915044..1916207	-	1164	WP_155309847.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-
GN112_RS08710	1916754..1917128	-	375	WP_155309848.1	GxxExxY protein	-
GN112_RS08715	1917606..1917827	-	222	WP_155309849.1	type II toxin-antitoxin system HicA family toxin	-
GN112_RS08720	1917824..1918135	-	312	WP_197743295.1	type II toxin-antitoxin system HicB family antitoxin	-
GN112_RS08725	1918401..1918781	-	381	WP_155309850.1	GxxExxY protein	-
GN112_RS08730	1919024..1919425	-	402	WP_155309851.1	type II toxin-antitoxin system VapC family toxin	Toxin
GN112_RS08735	1919422..1919652	-	231	WP_155309852.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GN112_RS08740	1921021..1921293	+	273	WP_155314093.1	hypothetical protein	-
GN112_RS08745	1921837..1922592	-	756	WP_155309853.1	hypothetical protein	-
GN112_RS08750	1923047..1923199	-	153	WP_155314178.1	HEPN domain-containing protein	-
GN112_RS08755	1923230..1923424	-	195	WP_155309854.1	hypothetical protein	-
GN112_RS08760	1923894..1924253	-	360	WP_155309855.1	four helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1840762..1954847	114085

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14876.35 Da
• Isoelectric Point: 6.9530

>T33450 WP_155309851.1 NZ_AP021879:c1919425-1919024 [Desulfosarcina ovata subsp. ovata]
MTVMLDTDICIYTIKKKPPSVLKRLEMCQTGAVVMSAVTFAELMNGAKKSRWVDDNVRRLNALSELIEVLAFDRDAAVVY
GDVRSDLEKRGLVIGGNDLFIAAHALSLGYPLVTNNQREFSRVKGLMIDNWLE

Nucleotide

• Length: 402 bp

>T33450 NZ_AP021879:c1919425-1919024 [Desulfosarcina ovata subsp. ovata]
ATGACGGTGATGTTAGACACGGATATTTGCATTTATACGATAAAAAAGAAGCCTCCCAGTGTCTTAAAACGGCTCGAAAT
GTGCCAGACCGGCGCTGTGGTCATGTCAGCTGTAACGTTTGCGGAATTAATGAACGGCGCAAAAAAAAGTCGTTGGGTTG
ATGACAATGTTCGCCGGTTGAATGCCCTGAGCGAGCTTATCGAGGTTCTTGCCTTTGACAGAGATGCCGCCGTGGTTTAC
GGAGATGTCCGCTCAGATCTTGAAAAAAGAGGACTGGTCATCGGTGGCAACGATCTGTTTATCGCTGCGCATGCGTTAAG
TCTGGGCTATCCCCTGGTGACCAATAACCAAAGGGAATTCAGTCGGGTCAAGGGTTTAATGATCGATAACTGGTTGGAAT
AG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8910.19 Da
• Isoelectric Point: 5.1367

>AT33450 WP_155309852.1 NZ_AP021879:c1919652-1919422 [Desulfosarcina ovata subsp. ovata]
METAKIFKSGNSQAVRLPKAYQFDVSEVQIFRRGDEIVLKRKPQNLSRVFELLTEMSDDFMEEGRCQPSMQEREPI

Nucleotide

• Length: 231 bp

>AT33450 NZ_AP021879:c1919652-1919422 [Desulfosarcina ovata subsp. ovata]
ATGGAAACCGCAAAGATTTTCAAAAGTGGCAACTCCCAAGCGGTCCGGTTGCCCAAAGCCTACCAATTCGATGTTTCAGA
AGTCCAAATATTTAGACGGGGTGACGAGATCGTTCTAAAACGAAAACCGCAAAATCTGTCCAGAGTGTTCGAGCTTTTAA
CCGAAATGTCGGATGATTTCATGGAAGAGGGACGCTGCCAACCGTCGATGCAGGAAAGAGAACCGATATGA