Detailed information of TA system TA033449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1062325..1062836
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GN112_RS04720
• Protein ID: WP_197743256.1
• Coordinates: 1062645..1062836 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GN112_RS04715
• Protein ID: WP_155309172.1
• Coordinates: 1062325..1062582 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS04695	1057649..1058935	+	1287	WP_155309168.1	3-isopropylmalate dehydratase large subunit	-
GN112_RS04700	1058950..1059474	+	525	WP_155309169.1	3-isopropylmalate dehydratase small subunit	-
GN112_RS04705	1059579..1059962	+	384	WP_155309170.1	four helix bundle protein	-
GN112_RS04710	1060430..1062223	+	1794	WP_155309171.1	SLC13 family permease	-
GN112_RS04715	1062325..1062582	+	258	WP_155309172.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GN112_RS04720	1062645..1062836	+	192	WP_197743256.1	Txe/YoeB family addiction module toxin	Toxin
GN112_RS04725	1063155..1065395	-	2241	WP_155309173.1	hypothetical protein	-
GN112_RS04730	1065448..1065954	-	507	WP_155309174.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-62)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7766.08 Da
• Isoelectric Point: 10.1391

>T33449 WP_197743256.1 NZ_AP021879:1062645-1062836 [Desulfosarcina ovata subsp. ovata]
MVKRIRELLKDILRHPEEGIGKPERLRFQLAGCWSRRINKEHRLIYQIEKDAITVISYRYHYE

Nucleotide

• Length: 192 bp

>T33449 NZ_AP021879:1062645-1062836 [Desulfosarcina ovata subsp. ovata]
ATGGTCAAGCGTATCCGCGAATTGCTGAAAGACATCCTGCGACACCCAGAAGAAGGCATCGGAAAACCGGAACGGTTAAG
GTTCCAGTTGGCCGGTTGCTGGTCTCGCCGCATCAACAAAGAACACCGCCTGATCTACCAAATCGAAAAAGACGCCATCA
CCGTCATCAGTTACCGATATCATTACGAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9557.88 Da
• Isoelectric Point: 6.9788

>AT33449 WP_155309172.1 NZ_AP021879:1062325-1062582 [Desulfosarcina ovata subsp. ovata]
MKAVTYTDARKNLKALIQEVCKNSESAVIVSSRSKDQAVLISLEDYQAMEETAYLLRSPANREHLERSLKEAQSGKLVTF
PTENL

Nucleotide

• Length: 258 bp

>AT33449 NZ_AP021879:1062325-1062582 [Desulfosarcina ovata subsp. ovata]
ATGAAAGCGGTAACCTACACTGACGCCAGAAAGAACCTCAAGGCGTTGATTCAGGAGGTATGCAAAAACTCGGAATCGGC
CGTCATCGTCAGCAGTCGCTCAAAGGACCAGGCGGTTCTGATTTCCCTTGAAGATTATCAGGCCATGGAGGAAACGGCCT
ATCTGTTGAGATCGCCGGCAAACCGGGAGCACCTGGAAAGATCTTTAAAAGAGGCGCAAAGCGGTAAATTGGTCACATTC
CCCACCGAGAATTTATGA