33447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 978203..978861 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GN112_RS04360 Protein ID WP_155309107.1
Coordinates 978203..978601 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GN112_RS04365 Protein ID WP_155309108.1
Coordinates 978631..978861 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS04315 973544..973960 - 417 WP_155309099.1 DUF86 domain-containing protein -
GN112_RS04320 973950..974375 - 426 WP_155309100.1 nucleotidyltransferase domain-containing protein -
GN112_RS04325 974524..974829 - 306 WP_155314130.1 nucleotidyltransferase domain-containing protein -
GN112_RS04330 974835..975272 - 438 WP_155309101.1 nucleotidyltransferase substrate binding protein -
GN112_RS04335 975269..975556 - 288 WP_155309102.1 hypothetical protein -
GN112_RS04340 975851..976717 - 867 WP_155309103.1 dTDP-4-dehydrorhamnose reductase -
GN112_RS04345 976933..977181 + 249 WP_155309104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GN112_RS04350 977182..977517 + 336 WP_155309105.1 type II toxin-antitoxin system PemK/MazF family toxin -
GN112_RS04355 977629..978189 - 561 WP_155309106.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
GN112_RS04360 978203..978601 - 399 WP_155309107.1 type II toxin-antitoxin system VapC family toxin Toxin
GN112_RS04365 978631..978861 - 231 WP_155309108.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GN112_RS04370 978938..979819 - 882 WP_155309109.1 glucose-1-phosphate thymidylyltransferase RfbA -
GN112_RS04375 979816..980895 - 1080 WP_155309110.1 dTDP-glucose 4,6-dehydratase -
GN112_RS04380 980935..981516 - 582 WP_155309111.1 winged helix-turn-helix transcriptional regulator -
GN112_RS04385 981791..982075 - 285 WP_155309112.1 helix-hairpin-helix domain-containing protein -
GN112_RS04390 982455..983810 + 1356 WP_155309113.1 sigma-54 dependent transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 937866..984784 46918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-126)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15613.12 Da        Isoelectric Point: 5.9817

>T33447 WP_155309107.1 NZ_AP021879:c978601-978203 [Desulfosarcina ovata subsp. ovata]
MASKRGYLIDTHCWLWWHIEPSKLSRKVIELVEDGSTTIFFSVVSAWEIVIKYRLQKLRLPLNPYEYIPKRLEISYMDVL
PVQLEHTLQVENLPDHHKDPFDRLLIAQAISEKLNLISSDCQMSSYDVEIVW

Download         Length: 399 bp

>T33447 NZ_AP021879:c978601-978203 [Desulfosarcina ovata subsp. ovata]
ATGGCAAGTAAAAGGGGCTATCTGATCGATACGCATTGCTGGCTGTGGTGGCATATTGAACCAAGCAAACTTAGCCGCAA
GGTCATCGAGCTCGTCGAGGACGGGAGCACAACCATTTTTTTTTCAGTGGTCAGTGCATGGGAAATTGTCATCAAATATA
GGTTGCAAAAGTTGAGACTCCCCTTGAATCCCTACGAATACATCCCAAAGCGTTTGGAGATAAGTTACATGGATGTGCTG
CCAGTCCAACTCGAACATACGTTGCAGGTTGAAAACCTGCCGGACCATCATAAGGATCCTTTTGACCGGCTGCTGATTGC
CCAAGCAATTTCAGAAAAATTGAACCTTATTTCCAGCGATTGTCAAATGTCATCTTACGATGTTGAGATCGTCTGGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8501.88 Da        Isoelectric Point: 10.0971

>AT33447 WP_155309108.1 NZ_AP021879:c978861-978631 [Desulfosarcina ovata subsp. ovata]
MLTINTHEAKTQLSRLLVRVSNGEEIIIAKSGKAVAKLVPIKRHTIKRKSGIDKGKGWIADDFDSPLPEELQAYFE

Download         Length: 231 bp

>AT33447 NZ_AP021879:c978861-978631 [Desulfosarcina ovata subsp. ovata]
ATGCTAACAATAAATACCCATGAGGCAAAAACGCAGCTATCGCGTTTATTGGTCCGGGTAAGCAATGGCGAGGAGATCAT
CATTGCCAAATCTGGCAAAGCGGTTGCAAAGTTAGTCCCGATTAAGCGCCACACGATTAAACGTAAATCCGGTATCGATA
AGGGCAAGGGCTGGATCGCCGATGATTTTGACTCCCCACTGCCCGAAGAACTGCAAGCCTATTTTGAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References