Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 976933..977517 | Replicon | chromosome |
| Accession | NZ_AP021879 | ||
| Organism | Desulfosarcina ovata subsp. ovata strain oXyS1 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | GN112_RS04350 | Protein ID | WP_155309105.1 |
| Coordinates | 977182..977517 (+) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | GN112_RS04345 | Protein ID | WP_155309104.1 |
| Coordinates | 976933..977181 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GN112_RS04300 | 972136..972435 | - | 300 | WP_155309096.1 | DUF86 domain-containing protein | - |
| GN112_RS04305 | 972645..973145 | - | 501 | WP_155309097.1 | GNAT family N-acetyltransferase | - |
| GN112_RS04310 | 973142..973429 | - | 288 | WP_155309098.1 | DUF1778 domain-containing protein | - |
| GN112_RS04315 | 973544..973960 | - | 417 | WP_155309099.1 | DUF86 domain-containing protein | - |
| GN112_RS04320 | 973950..974375 | - | 426 | WP_155309100.1 | nucleotidyltransferase domain-containing protein | - |
| GN112_RS04325 | 974524..974829 | - | 306 | WP_155314130.1 | nucleotidyltransferase domain-containing protein | - |
| GN112_RS04330 | 974835..975272 | - | 438 | WP_155309101.1 | nucleotidyltransferase substrate binding protein | - |
| GN112_RS04335 | 975269..975556 | - | 288 | WP_155309102.1 | hypothetical protein | - |
| GN112_RS04340 | 975851..976717 | - | 867 | WP_155309103.1 | dTDP-4-dehydrorhamnose reductase | - |
| GN112_RS04345 | 976933..977181 | + | 249 | WP_155309104.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| GN112_RS04350 | 977182..977517 | + | 336 | WP_155309105.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| GN112_RS04355 | 977629..978189 | - | 561 | WP_155309106.1 | dTDP-4-dehydrorhamnose 3,5-epimerase | - |
| GN112_RS04360 | 978203..978601 | - | 399 | WP_155309107.1 | type II toxin-antitoxin system VapC family toxin | - |
| GN112_RS04365 | 978631..978861 | - | 231 | WP_155309108.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GN112_RS04370 | 978938..979819 | - | 882 | WP_155309109.1 | glucose-1-phosphate thymidylyltransferase RfbA | - |
| GN112_RS04375 | 979816..980895 | - | 1080 | WP_155309110.1 | dTDP-glucose 4,6-dehydratase | - |
| GN112_RS04380 | 980935..981516 | - | 582 | WP_155309111.1 | winged helix-turn-helix transcriptional regulator | - |
| GN112_RS04385 | 981791..982075 | - | 285 | WP_155309112.1 | helix-hairpin-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 937866..984784 | 46918 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12286.20 Da Isoelectric Point: 8.2873
>T33446 WP_155309105.1 NZ_AP021879:977182-977517 [Desulfosarcina ovata subsp. ovata]
MTAYVPKQGDIIAISFDPPSGHEQKGRRPALVVSKDLFNRSTGLAIVCPVTNTDCGFPFHVAIPRNSKLTGFIMVEQVKS
VDFRARRAKRIEHGNDELLSEVLSILDACIY
MTAYVPKQGDIIAISFDPPSGHEQKGRRPALVVSKDLFNRSTGLAIVCPVTNTDCGFPFHVAIPRNSKLTGFIMVEQVKS
VDFRARRAKRIEHGNDELLSEVLSILDACIY
Download Length: 336 bp
>T33446 NZ_AP021879:977182-977517 [Desulfosarcina ovata subsp. ovata]
ATGACTGCTTATGTCCCGAAACAAGGGGACATCATCGCAATCTCATTTGATCCCCCATCCGGTCATGAGCAGAAGGGTCG
TCGCCCGGCCTTGGTTGTCAGCAAAGACCTGTTTAATCGAAGCACTGGTTTGGCCATAGTCTGCCCGGTTACGAACACGG
ATTGTGGTTTCCCCTTTCATGTCGCTATTCCGCGAAACAGCAAGCTGACAGGTTTTATTATGGTTGAGCAGGTTAAATCT
GTTGATTTCCGCGCTCGTCGAGCTAAACGAATCGAGCATGGCAATGATGAATTGCTGTCCGAGGTGCTGTCCATACTGGA
TGCCTGCATCTATTAG
ATGACTGCTTATGTCCCGAAACAAGGGGACATCATCGCAATCTCATTTGATCCCCCATCCGGTCATGAGCAGAAGGGTCG
TCGCCCGGCCTTGGTTGTCAGCAAAGACCTGTTTAATCGAAGCACTGGTTTGGCCATAGTCTGCCCGGTTACGAACACGG
ATTGTGGTTTCCCCTTTCATGTCGCTATTCCGCGAAACAGCAAGCTGACAGGTTTTATTATGGTTGAGCAGGTTAAATCT
GTTGATTTCCGCGCTCGTCGAGCTAAACGAATCGAGCATGGCAATGATGAATTGCTGTCCGAGGTGCTGTCCATACTGGA
TGCCTGCATCTATTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 9164.62 Da Isoelectric Point: 9.7674
>AT33446 WP_155309104.1 NZ_AP021879:976933-977181 [Desulfosarcina ovata subsp. ovata]
MLAKIQKWGNSQGLRLAKNLLADAKLGVGDEVDIRVKDGIMIVTPTQKIRGKHRLEDLVARIPENYQPGEANWGEPMGKE
AW
MLAKIQKWGNSQGLRLAKNLLADAKLGVGDEVDIRVKDGIMIVTPTQKIRGKHRLEDLVARIPENYQPGEANWGEPMGKE
AW
Download Length: 249 bp
>AT33446 NZ_AP021879:976933-977181 [Desulfosarcina ovata subsp. ovata]
ATGCTTGCAAAAATTCAGAAATGGGGCAATAGCCAAGGCCTTCGCCTTGCTAAGAATCTACTTGCAGATGCAAAACTAGG
CGTTGGTGACGAGGTGGATATCCGTGTCAAAGACGGTATTATGATCGTTACACCGACCCAAAAGATTCGTGGTAAGCACA
GGCTTGAAGATCTTGTCGCACGGATTCCTGAAAATTACCAGCCCGGTGAAGCCAACTGGGGTGAGCCGATGGGTAAGGAG
GCCTGGTAA
ATGCTTGCAAAAATTCAGAAATGGGGCAATAGCCAAGGCCTTCGCCTTGCTAAGAATCTACTTGCAGATGCAAAACTAGG
CGTTGGTGACGAGGTGGATATCCGTGTCAAAGACGGTATTATGATCGTTACACCGACCCAAAAGATTCGTGGTAAGCACA
GGCTTGAAGATCTTGTCGCACGGATTCCTGAAAATTACCAGCCCGGTGAAGCCAACTGGGGTGAGCCGATGGGTAAGGAG
GCCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|