Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 973544..974375 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag GN112_RS04315 Protein ID WP_155309099.1
Coordinates 973544..973960 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag GN112_RS04320 Protein ID WP_155309100.1
Coordinates 973950..974375 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS04280 969294..970421 - 1128 WP_155309092.1 putative DNA binding domain-containing protein -
GN112_RS04285 970694..971119 - 426 WP_155309093.1 nucleotidyltransferase domain-containing protein -
GN112_RS04290 971131..971550 - 420 WP_155309094.1 DUF86 domain-containing protein -
GN112_RS04295 971547..971969 - 423 WP_155309095.1 hypothetical protein -
GN112_RS04300 972136..972435 - 300 WP_155309096.1 DUF86 domain-containing protein -
GN112_RS04305 972645..973145 - 501 WP_155309097.1 GNAT family N-acetyltransferase -
GN112_RS04310 973142..973429 - 288 WP_155309098.1 DUF1778 domain-containing protein -
GN112_RS04315 973544..973960 - 417 WP_155309099.1 DUF86 domain-containing protein Toxin
GN112_RS04320 973950..974375 - 426 WP_155309100.1 nucleotidyltransferase domain-containing protein Antitoxin
GN112_RS04325 974524..974829 - 306 WP_155314130.1 nucleotidyltransferase domain-containing protein -
GN112_RS04330 974835..975272 - 438 WP_155309101.1 nucleotidyltransferase substrate binding protein -
GN112_RS04335 975269..975556 - 288 WP_155309102.1 hypothetical protein -
GN112_RS04340 975851..976717 - 867 WP_155309103.1 dTDP-4-dehydrorhamnose reductase -
GN112_RS04345 976933..977181 + 249 WP_155309104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GN112_RS04350 977182..977517 + 336 WP_155309105.1 type II toxin-antitoxin system PemK/MazF family toxin -
GN112_RS04355 977629..978189 - 561 WP_155309106.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
GN112_RS04360 978203..978601 - 399 WP_155309107.1 type II toxin-antitoxin system VapC family toxin -
GN112_RS04365 978631..978861 - 231 WP_155309108.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 937866..984784 46918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(13-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(16-104)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15900.30 Da        Isoelectric Point: 6.4880

>T33445 WP_155309099.1 NZ_AP021879:c973960-973544 [Desulfosarcina ovata subsp. ovata]
MTSDVLLNKVAIIERCLSRIEEEYRGHEQELDNNYTRQDSIILNLQRACEASIDAAMHLVRVRKLGVPQESRDAFDMLGE
ADLLKPVLRDRLKSMVGFRNVAVHGYRKLNIEIVRTIVETRLGDFRELAKVVLQEGHE

Download         Length: 417 bp

>T33445 NZ_AP021879:c973960-973544 [Desulfosarcina ovata subsp. ovata]
ATGACCAGTGATGTTTTACTGAATAAAGTTGCCATCATTGAGCGGTGCCTGTCTCGCATCGAGGAGGAATACCGTGGACA
CGAGCAGGAGTTGGATAACAACTATACTCGACAGGATTCCATTATTCTCAATTTGCAACGGGCCTGTGAAGCATCGATTG
ACGCTGCCATGCATCTCGTCCGGGTGCGTAAATTGGGGGTGCCGCAGGAATCCAGAGACGCTTTCGATATGCTTGGCGAA
GCTGACCTGTTGAAACCGGTATTGCGTGATCGCCTCAAGTCGATGGTCGGATTCCGCAATGTTGCTGTACACGGCTATCG
CAAACTGAACATTGAAATTGTTCGTACCATTGTTGAAACACGCCTTGGTGATTTCCGCGAGTTGGCCAAAGTGGTATTGC
AGGAAGGGCATGAGTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15725.85 Da        Isoelectric Point: 4.7851

>AT33445 WP_155309100.1 NZ_AP021879:c974375-973950 [Desulfosarcina ovata subsp. ovata]
MSLNVLLNSQLQKELIEEICSTVHSCVAIYRFGSWGTAAQRKGSDIDIAVLAASPLDPVGRWDLAQKLASIAGRDVDLVD
LLRASTVLRMQVVAYGERLHCVDAEAAERFEDNVFSSYAKLNEERRLILEDVNRRGSVYDQ

Download         Length: 426 bp

>AT33445 NZ_AP021879:c974375-973950 [Desulfosarcina ovata subsp. ovata]
ATGTCGCTGAATGTGTTGTTGAATTCACAATTGCAGAAGGAACTTATTGAAGAGATCTGCTCCACTGTCCACAGTTGTGT
GGCGATTTATCGCTTTGGCTCATGGGGCACGGCTGCTCAGAGAAAAGGGAGCGATATAGACATTGCCGTCTTGGCTGCAT
CGCCGCTTGATCCGGTTGGTCGTTGGGATCTTGCCCAGAAGTTGGCATCAATAGCTGGTCGGGATGTTGACCTGGTCGAT
TTGCTGAGGGCTTCAACGGTTTTACGTATGCAGGTGGTGGCGTATGGTGAGCGGCTTCATTGTGTTGATGCCGAAGCGGC
TGAACGTTTTGAAGATAACGTATTTTCCAGCTATGCCAAGCTCAATGAGGAGCGCCGCTTGATTCTTGAGGATGTGAATA
GGCGAGGGAGTGTGTATGACCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References