Detailed information of TA system TA033442

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 437999..438573
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GN112_RS02050
• Protein ID: WP_155308698.1
• Coordinates: 437999..438295 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GN112_RS02055
• Protein ID: WP_155308699.1
• Coordinates: 438292..438573 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS02035	433297..434484	-	1188	WP_155308695.1	12,18-didecarboxysiroheme deacetylase	-
GN112_RS02040	434491..436275	-	1785	WP_155308696.1	AAA family ATPase	-
GN112_RS02045	436818..437792	+	975	WP_155308697.1	PHP domain-containing protein	-
GN112_RS02050	437999..438295	-	297	WP_155308698.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GN112_RS02055	438292..438573	-	282	WP_155308699.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GN112_RS02060	439466..439744	+	279	WP_155308700.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GN112_RS02065	439762..440049	+	288	WP_155308701.1	HigA family addiction module antidote protein	-
GN112_RS02070	441003..441836	-	834	WP_155308702.1	Retron-type reverse transcriptase	-
GN112_RS02075	441817..442833	-	1017	WP_155308703.1	CRISPR-associated endonuclease Cas1	-
GN112_RS02080	442830..443159	-	330	WP_162458737.1	CRISPR-associated endonuclease Cas2	-
GN112_RS02085	443209..443493	-	285	WP_155308705.1	CRISPR-associated endonuclease Cas2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	421511..453974	32463

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-73)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11384.29 Da
• Isoelectric Point: 5.8717

>T33442 WP_155308698.1 NZ_AP021879:c438295-437999 [Desulfosarcina ovata subsp. ovata]
MKIVWSPLAIERASEIAEYIAQDKPSAAEKWLDTIFTKVETLKSAPEIGRVVPEIRNSQFRDLIYGNYRIIYRIEEKQIS
ILTIRHGMQILPIDEILV

Nucleotide

• Length: 297 bp

>T33442 NZ_AP021879:c438295-437999 [Desulfosarcina ovata subsp. ovata]
ATGAAAATAGTTTGGTCTCCGTTAGCCATTGAACGGGCATCAGAAATTGCCGAATATATTGCTCAAGATAAACCATCAGC
TGCAGAAAAATGGCTTGACACAATCTTTACCAAGGTAGAGACGCTAAAATCCGCACCCGAAATTGGAAGAGTTGTTCCTG
AAATTCGAAATAGTCAATTTCGGGATCTAATTTATGGTAATTACAGAATTATATACCGTATTGAAGAGAAGCAGATATCT
ATTCTTACGATTCGCCACGGCATGCAGATACTACCGATCGATGAGATTCTGGTATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10695.35 Da
• Isoelectric Point: 7.4699

>AT33442 WP_155308699.1 NZ_AP021879:c438573-438292 [Desulfosarcina ovata subsp. ovata]
MQRLKISHDIKPLSEFRTGIANFIKQVHDTKRPVIITQHGKGVAVLLDVHEYETMQEKLELLSDVQISLNQLENGEGVLH
EDAKQSILRRIQK

Nucleotide

• Length: 282 bp

>AT33442 NZ_AP021879:c438573-438292 [Desulfosarcina ovata subsp. ovata]
ATGCAAAGATTAAAAATCAGTCATGATATCAAACCCTTGTCCGAATTTAGGACTGGTATAGCGAATTTTATTAAACAAGT
TCATGATACAAAACGACCAGTTATCATTACTCAGCATGGAAAGGGAGTTGCGGTTTTATTGGATGTTCATGAATATGAAA
CAATGCAGGAGAAACTCGAACTTCTGTCAGACGTCCAAATATCACTAAACCAACTCGAAAATGGTGAAGGGGTTCTTCAT
GAAGATGCAAAGCAAAGCATCCTCAGAAGGATTCAAAAATGA