Detailed information of TA system TA033441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/Txe-YefM
• Location: 257283..257785
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GN112_RS01210
• Protein ID: WP_155308547.1
• Coordinates: 257519..257785 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GN112_RS01205
• Protein ID: WP_083456022.1
• Coordinates: 257283..257525 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS01175	252343..253737	+	1395	WP_155308543.1	IS66 family transposase	-
GN112_RS01180	253761..254045	+	285	WP_155308544.1	hypothetical protein	-
GN112_RS01185	254549..254995	+	447	WP_155308508.1	hypothetical protein	-
GN112_RS01190	255544..255732	-	189	WP_155308545.1	type II toxin-antitoxin system HicA family toxin	-
GN112_RS01195	255713..255949	-	237	WP_054699606.1	type II toxin-antitoxin system HicB family antitoxin	-
GN112_RS01200	256298..256942	+	645	Protein_236	group II intron reverse transcriptase/maturase	-
GN112_RS01205	257283..257525	+	243	WP_083456022.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GN112_RS01210	257519..257785	+	267	WP_155308547.1	Txe/YoeB family addiction module toxin	Toxin
GN112_RS01215	257985..259379	-	1395	WP_155308548.1	IS66 family transposase	-
GN112_RS01220	259590..259910	+	321	WP_155308549.1	hypothetical protein	-
GN112_RS01225	260976..261212	+	237	WP_155308550.1	DUF433 domain-containing protein	-
GN112_RS01230	261209..261577	+	369	WP_155308551.1	DUF5615 family PIN-like protein	-
GN112_RS01235	261957..262412	+	456	WP_162458721.1	flavodoxin family protein	-
GN112_RS01240	262509..262721	+	213	WP_155308553.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	208165..261577	53412

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10339.05 Da
• Isoelectric Point: 9.9940

>T33441 WP_155308547.1 NZ_AP021879:257519-257785 [Desulfosarcina ovata subsp. ovata]
MVNYKVVFTKQAQKDAKKLSAAGLKTKAENIIEILRENPYQTPPFYEKLVGDLAGAYSRRINIQHRLVYEVIEDQKIVKV
IRMWTHYE

Nucleotide

• Length: 267 bp

>T33441 NZ_AP021879:257519-257785 [Desulfosarcina ovata subsp. ovata]
TTGGTAAATTACAAGGTCGTTTTTACAAAACAAGCACAAAAAGACGCGAAAAAATTATCCGCCGCCGGCCTCAAGACAAA
GGCCGAAAATATTATCGAAATATTGCGGGAAAATCCTTATCAGACCCCTCCTTTCTATGAAAAACTTGTAGGCGATTTAG
CTGGCGCATATTCCCGTCGTATAAACATTCAACACCGACTGGTCTATGAGGTTATCGAAGACCAAAAGATTGTAAAAGTT
ATCCGTATGTGGACACATTATGAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9117.39 Da
• Isoelectric Point: 4.4488

>AT33441 WP_083456022.1 NZ_AP021879:257283-257525 [Desulfosarcina ovata subsp. ovata]
MPTLSATEARSKLYRLIDQTALSHEPIVITSKRGNAVLLSEDDWRAIQETMYLLNIPGMRESIREGLATPVEDCKEELDW

Nucleotide

• Length: 243 bp

>AT33441 NZ_AP021879:257283-257525 [Desulfosarcina ovata subsp. ovata]
ATGCCGACTTTATCAGCCACTGAGGCAAGATCGAAACTTTACCGTCTTATCGACCAAACCGCATTGTCCCATGAACCAAT
TGTAATTACAAGTAAAAGAGGCAATGCTGTTCTGCTATCCGAGGACGATTGGCGGGCAATCCAAGAAACAATGTACCTGT
TAAACATCCCAGGCATGCGCGAGTCAATTCGTGAAGGTTTGGCAACACCTGTCGAGGATTGCAAAGAGGAACTCGATTGG
TAA