Detailed information of TA system TA033440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 229729..230323
• Replicon: chromosome
• Accession: NZ_AP021879
• Organism: Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GN112_RS01075
• Protein ID: WP_155308527.1
• Coordinates: 229729..229935 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GN112_RS01080
• Protein ID: WP_155308528.1
• Coordinates: 229928..230323 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN112_RS01050	224982..225512	+	531	WP_155308522.1	hypothetical protein	-
GN112_RS01055	225536..226549	-	1014	WP_155308523.1	site-specific integrase	-
GN112_RS01060	226536..227552	-	1017	WP_197743229.1	tyrosine-type recombinase/integrase	-
GN112_RS01065	227519..228748	-	1230	WP_155308525.1	tyrosine-type recombinase/integrase	-
GN112_RS01070	228897..229550	+	654	WP_155308526.1	transposase	-
GN112_RS01075	229729..229935	+	207	WP_155308527.1	type II toxin-antitoxin system HicA family toxin	Toxin
GN112_RS01080	229928..230323	+	396	WP_155308528.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GN112_RS01085	230836..232167	+	1332	WP_155308529.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	208165..261577	53412

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-125)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7831.19 Da
• Isoelectric Point: 10.8719

>T33440 WP_155308527.1 NZ_AP021879:229729-229935 [Desulfosarcina ovata subsp. ovata]
MDSKKIIKAIKKKGWVHIRTTGGHWHFHHPEQAGIVTVPHPKKDIPIGTLKSIEKQANMEFKQEVRNV

Nucleotide

• Length: 207 bp

>T33440 NZ_AP021879:229729-229935 [Desulfosarcina ovata subsp. ovata]
ATGGATAGCAAAAAAATCATAAAGGCAATAAAAAAGAAAGGCTGGGTGCATATCCGTACAACTGGAGGTCATTGGCATTT
CCATCATCCTGAGCAAGCAGGAATTGTCACTGTGCCCCACCCCAAAAAAGATATTCCTATCGGCACCCTAAAAAGTATTG
AGAAACAAGCCAATATGGAATTTAAGCAGGAGGTTCGTAATGTCTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14358.19 Da
• Isoelectric Point: 6.3248

>AT33440 WP_155308528.1 NZ_AP021879:229928-230323 [Desulfosarcina ovata subsp. ovata]
MSNYIAVVHKNSSSDYGVSFPDFPGCITGDKSIDTVKDLSSEALSGHIQTMREFGEKIPNPTKLDDIVADQDYSDAIAFF
VVSAPEVKSKTVRVNITLPENILHQIDVTAKKRGMSRSSFLTHAAQNVMHS

Nucleotide

• Length: 396 bp

>AT33440 NZ_AP021879:229928-230323 [Desulfosarcina ovata subsp. ovata]
ATGTCTAATTATATCGCGGTAGTGCATAAAAATTCTTCAAGTGATTATGGGGTATCATTTCCTGATTTTCCTGGTTGTAT
AACAGGAGATAAATCTATTGATACAGTGAAAGACCTTTCAAGTGAAGCATTATCTGGCCATATTCAGACCATGAGAGAGT
TCGGAGAAAAAATCCCTAATCCAACAAAGTTAGATGACATTGTTGCAGATCAAGATTATTCGGATGCAATTGCTTTTTTT
GTTGTATCTGCCCCAGAAGTAAAATCAAAAACTGTTCGAGTGAATATCACATTACCGGAAAATATATTGCATCAAATAGA
TGTAACTGCAAAAAAAAGAGGTATGTCACGGTCATCATTTTTAACTCATGCTGCTCAAAATGTGATGCATTCATAA