Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 7297916..7299573 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag GN113_RS31630 Protein ID WP_155326212.1
Coordinates 7298266..7299573 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag GN113_RS31625 Protein ID WP_155325286.1
Coordinates 7297916..7298269 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS31600 7293075..7293866 + 792 WP_155325283.1 transporter substrate-binding domain-containing protein -
GN113_RS37355 7294007..7294573 - 567 Protein_6279 transposase -
GN113_RS31610 7295610..7295981 + 372 WP_155320799.1 transposase zinc-binding domain-containing protein -
GN113_RS31615 7296082..7296918 + 837 WP_173178989.1 transposase -
GN113_RS31620 7297051..7297464 - 414 WP_155325285.1 hypothetical protein -
GN113_RS31625 7297916..7298269 + 354 WP_155325286.1 helix-turn-helix domain-containing protein Antitoxin
GN113_RS31630 7298266..7299573 + 1308 WP_155326212.1 type II toxin-antitoxin system HipA family toxin Toxin
GN113_RS31635 7300371..7301063 + 693 WP_155320948.1 hypothetical protein -
GN113_RS31640 7301060..7301296 - 237 WP_155320949.1 hypothetical protein -
GN113_RS31645 7301432..7302967 + 1536 WP_173179988.1 hypothetical protein -
GN113_RS31650 7303745..7304560 - 816 WP_197910360.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48433.93 Da        Isoelectric Point: 7.1507

>T33438 WP_155326212.1 NZ_AP021876:7298266-7299573 [Desulfosarcina ovata subsp. sediminis]
MSTYAQVNLWGRTIGAVALQDGQTVAAFEYDPAFAKSGIEIAPLTMPLSTRVYAFPELAYRTFHGLPGLLADSLPDRFGN
ALIDAWLATQGRSAESFNAVERLCYVGQRGTGALEFAPVIGPRNRRSMRLNVDRLVELASQILSQRNHLADSFAGPQKAK
ALANILRVGTSAGGARAKAIIALNPETDEVRSGQVDAGDGFEYWLLKFDGVGGNRDKELEDPRGYGVVEYAYWKMATDAG
ITMSECRLLEENDRRHFMTRRFDRGPRGEKLHMQSLCAMAHLDFNLAGVYAYEQALLVIRQLGLSMDAVEEQFRRMVFNI
VARNQDDHVKNIAFMMTPDGAWSLSPAFDVTYSYNPDGAWTGSHQMTLNGKRDGFTLADFRACARAAMMKRGRAEAIIEA
VQRVVARWRDYADDAGVPSDWRDRIHATLRLERFG

Download         Length: 1308 bp

>T33438 NZ_AP021876:7298266-7299573 [Desulfosarcina ovata subsp. sediminis]
ATGAGCACCTATGCGCAAGTGAACCTCTGGGGGCGGACCATTGGTGCGGTCGCCCTTCAGGATGGCCAGACCGTCGCCGC
CTTTGAATACGACCCCGCCTTCGCGAAGAGCGGCATCGAAATCGCTCCCCTGACGATGCCGCTTTCCACCCGGGTGTATG
CGTTTCCGGAACTGGCCTACCGGACCTTTCACGGCCTGCCCGGTCTGCTTGCCGATTCCTTGCCCGACCGTTTCGGCAAC
GCGCTGATCGATGCCTGGCTAGCGACTCAGGGCCGATCGGCGGAATCCTTCAATGCTGTCGAGCGACTCTGTTATGTCGG
GCAACGGGGCACGGGGGCACTTGAATTCGCTCCGGTGATCGGCCCGCGCAACCGGCGTTCCATGCGGCTGAATGTCGACC
GGCTCGTCGAACTGGCGTCGCAAATCCTCAGCCAGCGCAATCATTTGGCCGATTCGTTTGCCGGCCCGCAGAAAGCCAAG
GCCCTGGCGAATATTCTGCGCGTCGGTACGTCTGCGGGCGGTGCCCGGGCCAAGGCGATTATCGCCTTGAACCCGGAAAC
GGATGAGGTCCGTTCGGGGCAGGTCGACGCCGGAGATGGCTTTGAGTACTGGCTGCTCAAATTCGACGGGGTCGGCGGCA
ACCGGGACAAGGAACTGGAAGACCCCAGGGGCTACGGTGTTGTCGAATACGCCTATTGGAAGATGGCCACCGATGCCGGC
ATTACCATGAGCGAGTGCCGCCTGCTTGAGGAGAATGACCGCCGGCATTTCATGACCCGGCGCTTCGATCGCGGCCCCCG
GGGGGAAAAGCTTCACATGCAGTCGCTGTGCGCCATGGCCCATTTGGATTTCAATCTGGCCGGTGTTTATGCCTACGAGC
AGGCCCTGTTGGTCATCCGGCAGCTGGGACTCTCCATGGACGCGGTGGAAGAGCAGTTCCGGCGCATGGTCTTCAACATC
GTCGCCCGCAACCAGGATGACCATGTGAAGAATATCGCTTTTATGATGACACCCGACGGTGCATGGTCACTCTCACCCGC
ATTTGACGTGACCTACAGCTACAACCCCGACGGTGCATGGACCGGCAGCCATCAGATGACACTGAACGGCAAACGGGACG
GTTTCACCCTGGCGGATTTCCGGGCCTGCGCCAGGGCGGCCATGATGAAACGCGGGCGGGCCGAGGCGATCATTGAAGCA
GTGCAGCGCGTCGTTGCCCGTTGGCGCGATTATGCCGACGATGCCGGGGTGCCATCGGACTGGCGGGATCGGATCCACGC
CACCCTACGGTTAGAACGGTTTGGATGA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13098.14 Da        Isoelectric Point: 10.5707

>AT33438 WP_155325286.1 NZ_AP021876:7297916-7298269 [Desulfosarcina ovata subsp. sediminis]
MTIDKLSKLMTDDAILAELGFRMARCRIDRQLTQAALAHQAGVSKRTVERIEAGASAQMVSVIRICRVLDLVAGIDQWIP
QPDPRPMDLVARKGRTRQRASSSRKTQGADEPWTWDP

Download         Length: 354 bp

>AT33438 NZ_AP021876:7297916-7298269 [Desulfosarcina ovata subsp. sediminis]
ATGACGATTGACAAACTATCAAAACTCATGACCGACGATGCGATTCTGGCCGAGTTGGGCTTTCGCATGGCCCGGTGCCG
TATCGACCGGCAGCTGACCCAGGCGGCACTGGCTCACCAGGCCGGTGTTTCCAAACGCACCGTGGAGCGCATCGAGGCCG
GCGCATCGGCCCAGATGGTGAGTGTCATCCGTATCTGCAGGGTTTTGGATCTCGTCGCCGGGATCGATCAGTGGATTCCC
CAGCCGGACCCCCGGCCGATGGATCTGGTCGCCCGCAAGGGCCGGACGCGCCAGCGGGCCTCATCCAGCCGCAAGACCCA
GGGCGCGGATGAACCATGGACCTGGGACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References