Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 6326880..6327757 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GN113_RS27405 Protein ID WP_155324721.1
Coordinates 6326880..6327350 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GN113_RS27410 Protein ID WP_173179867.1
Coordinates 6327347..6327757 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS37340 6322105..6322248 + 144 Protein_5452 phage integrase N-terminal SAM-like domain-containing protein -
GN113_RS37135 6322231..6322916 + 686 Protein_5453 site-specific integrase -
GN113_RS27380 6323577..6324062 + 486 WP_155322046.1 helix-turn-helix domain-containing protein -
GN113_RS27385 6323987..6324622 + 636 Protein_5455 IS630 family transposase -
GN113_RS27390 6324722..6325393 + 672 WP_155324719.1 hypothetical protein -
GN113_RS27395 6325429..6325611 + 183 WP_155326167.1 transposase zinc-binding domain-containing protein -
GN113_RS27400 6325722..6326351 + 630 WP_155324720.1 hypothetical protein -
GN113_RS27405 6326880..6327350 - 471 WP_155324721.1 RES family NAD+ phosphorylase Toxin
GN113_RS27410 6327347..6327757 - 411 WP_173179867.1 DUF2384 domain-containing protein Antitoxin
GN113_RS27415 6327890..6328156 + 267 WP_197910332.1 hypothetical protein -
GN113_RS27420 6328367..6328696 + 330 WP_155312586.1 DUF134 domain-containing protein -
GN113_RS27425 6328737..6329081 + 345 WP_155312587.1 DUF5320 domain-containing protein -
GN113_RS27430 6329186..6329467 - 282 WP_155312588.1 hypothetical protein -
GN113_RS27435 6329688..6330983 - 1296 WP_155324723.1 dicarboxylate/amino acid:cation symporter -
GN113_RS27440 6330985..6331899 - 915 WP_173179869.1 transporter substrate-binding domain-containing protein -
GN113_RS27445 6332199..6332480 - 282 Protein_5467 polyphosphate:AMP phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(4-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(18-79)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17337.65 Da        Isoelectric Point: 5.6268

>T33436 WP_155324721.1 NZ_AP021876:c6327350-6326880 [Desulfosarcina ovata subsp. sediminis]
MIRAWRIVKSIYKDSAFNGEGARLYGGRWNTPGHPAVYVASSQALAVLEIMANGLMIEDAENFVFVSVNFPETFVQEIST
TDLSQNWATSPAPESTKIIGDRWLASGFSVALKVPSVIVPDECNYLLNPHHPDFASLAIGSSRFFRIDTRLFNYYG

Download         Length: 471 bp

>T33436 NZ_AP021876:c6327350-6326880 [Desulfosarcina ovata subsp. sediminis]
TTGATTCGAGCCTGGCGAATCGTCAAATCGATCTACAAGGACTCGGCATTTAACGGTGAAGGTGCCCGGCTTTATGGTGG
ACGCTGGAACACTCCCGGTCATCCGGCAGTCTATGTTGCCAGTTCGCAGGCCCTTGCCGTTCTGGAAATCATGGCTAACG
GGCTGATGATCGAGGATGCTGAAAATTTCGTTTTTGTGTCGGTGAATTTTCCTGAAACGTTTGTGCAGGAGATCTCAACT
ACGGATTTATCGCAAAACTGGGCGACTTCCCCGGCACCTGAAAGCACCAAAATTATAGGTGATCGCTGGTTAGCATCAGG
ATTTTCCGTTGCTCTAAAAGTACCCAGTGTAATCGTTCCGGATGAGTGCAACTACCTTCTAAACCCGCATCACCCTGATT
TTGCTTCCCTGGCCATTGGTTCCTCTCGGTTTTTTAGGATCGACACACGTCTGTTTAACTATTACGGATAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15172.40 Da        Isoelectric Point: 8.5611

>AT33436 WP_173179867.1 NZ_AP021876:c6327757-6327347 [Desulfosarcina ovata subsp. sediminis]
MEYQPNPALDIGTHSQSELIASIRAGFPLEVFKRTAKQLTMTEKQLAALTNITTSTLTRRKKEGRLTKDESEKLFRIIRV
FNRAVDVFGATDSAVSWLTRPLPALAGVRPLDYIDTDIGTIEVENVLGRIEHGVFS

Download         Length: 411 bp

>AT33436 NZ_AP021876:c6327757-6327347 [Desulfosarcina ovata subsp. sediminis]
ATGGAATATCAACCCAATCCAGCCTTGGATATCGGAACGCATAGTCAGTCCGAGCTGATCGCCAGCATTCGCGCCGGATT
TCCACTGGAAGTGTTTAAACGCACGGCCAAGCAGCTGACCATGACTGAAAAACAGCTGGCGGCCCTAACCAATATCACCA
CCAGTACACTGACTCGCCGCAAGAAAGAAGGCCGGCTTACCAAAGACGAATCTGAAAAGCTGTTTCGCATCATACGGGTG
TTCAACCGGGCGGTTGACGTATTCGGGGCGACGGATTCTGCGGTATCCTGGCTGACGAGACCGTTACCGGCGCTAGCCGG
CGTTCGGCCGCTGGACTACATCGATACGGATATTGGAACGATAGAGGTGGAGAACGTGTTGGGCCGGATTGAGCACGGGG
TGTTCTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References